Publications by authors named "Aahir Srinath"
Article Synopsis
- E-cigarettes are thought to be safer than regular cigarettes because their liquids don't have known cancer-causing chemicals.
- However, studies showed that two main ingredients in e-cigarettes, PG/VG and nicotine, can actually help tumors grow and spread more aggressively in test models.
- Mice exposed to these e-cigarette ingredients developed tumors with a lot of harmful immune cells, but treatment with a specific medicine helped reduce tumor spread without harming the mice.
T cell responses are inhibited by acidic environments. T cell receptor (TCR)-induced protein phosphorylation is negatively regulated by dephosphorylation and/or ubiquitination, but the mechanisms underlying sensitivity to acidic environments are not fully understood. Here, we found that TCR stimulation induced a molecular complex of Cbl-b, an E3-ubiquitin ligase, with STS1, a pH-sensitive unconventional phosphatase.
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