In Silico Identification of Novel Derivatives of Rifampicin Targeting Ribonuclease VapC2 of H37Rv: Rifampicin Derivatives Target VapC2 of H37Rv.

The emergence of multi-drug-resistant () strains has rendered many of the currently available anti-TB drugs ineffective. Hence, there is a pressing need to discover new potential drug targets/candidates. In this study, attempts have been made to identify novel inhibitors of the ribonuclease VapC2 of H37Rv using various computational techniques.

Engineering a Carotenoid-Overproducing Strain of Azospirillum brasilense for Heterologous Production of Geraniol and Amorphadiene.

and have been used extensively for heterologous production of a variety of secondary metabolites. Neither has an endogenous high-flux isoprenoid pathway, required for the production of terpenoids. , a nonphotosynthetic GRAS (generally recognized as safe) bacterium, produces carotenoids in the presence of light.

RelQ Mediates the Expression of β-Lactam Resistance in Methicillin-Resistant .

An induced stringent response, which is established by an increased level of (p)ppGpp, is required for the expression of β-lactam resistance in methicillin-resistant (MRSA). However, it is not clear whether RSH (enzyme mediating stringent response to amino acid starvation) or small alarmone synthetases (SASs) are involved in the maintenance of (p)ppGpp level in response to β-lactams. Since the genome encodes two active SASs (RelP and RelQ), their contribution to the expression of β-lactam resistance in MRSA was investigated.