Association of promoter methylation of and mutations in non-small cell lung carcinoma in Kashmiri population (India).

Background: Non-small cell lung carcinoma (NSCLC) incidence and progression is increasing because of genetic and epigenetic changes. The mutations in the Kirsten rat sarcoma () are the most frequently oncogene aberrations in lung carcinoma patients. A candidate tumor suppressor gene (TSG) Ras Association Domain Family 1 Isoform A (), is silenced by promoter hypermethylation in several human malignancies including non-small cell lung carcinoma (NSCLC).