[Antenatal ultrasonic diagnosis of nephro-urologic malformations].

The authors expose their results in the field of prenatal diagnosis of renal and urinary tract malformations. They describe normal and abnormal ultrasonographic aspects of kidneys, ureters and bladder with special reference to prognosis and therapeutic decisions.

Biosynthesis of a putative gonadotropin receptor component by rat leydig cells: isolation of a radiolabeled acidic protein of 79,000 molecular weight by affinity chromatography.

The Leydig cells of the testis are known to possess high affinity receptors for luteinizing hormone and human chorionic gonadotropin (hCG), but no information concerning the synthesis of these receptors is available yet. In order to investigate this question, we have purified crude rat interstitial cell preparations on discontinuous Percoll gradients, and Leydig cells recovered from fractions demonstrating maximum testosterone production and hCG binding capacity were incubated for 17 h in a culture medium containing [35S]methionine. Radioactive proteins solubilized with Triton X-100 were submitted to affinity chromatography on a resin consisting of hCG covalently linked to agarose.

[Echographic detection of chromosomal anomalies apropos of trisomy 13 and 18].

Some multisystemic abnormalities associations which can be found by ultrasound examination are sometimes chromosome anomalies and amniocentesis must be performed for confirmation. By ultrasonography we can now reach a new objective element: the fetus extremities. Limbs anomalies, such as polydactily, club-feet and/or club-hands must lead to perform amniocentesis in order to assess or not a possible 13 or 18 trisomy.

[Percutaneous nephrostomy in utero for bilateral foetal hydronephrosis].

Left percutaneous nephrostomy was performed in a 30-week foetus with bilateral hydronephrosis due to abnormal pyelo-ureteral junction. Puncture of the pelvis and insertion of a 5 cm long F8 Malecot catheter were carried out under ultrasonography. The end of the catheter was left free in the amniotic fluid.

[Prenatal ultrasound measurement of the interorbital distance. Method of recognizing lesser degrees of holoprosencephaly].

The antenatal diagnosis of holoprosencephaly seems to need study of the interhemispheric fissure which may or not be complete in lesser degrees of that disease, but also measuring of interorbital distance (I.O.D.

[The antenatal diagnosis of Bonnevie-Ullrich's syndrome. The role of ultrasound (author's transl)].

The authors report four cases of Bonnevie-Ullrich's syndrome where the diagnosis was made by ultrasound. The typical picture is of a cystic retrocervical hygroma with generalised lymphoedema which is more marked in the lower limbs and on the backs of the hands and feet, together with ascites. This syndrome adds up to Turner's syndrome.

Laminated diatomaceous sediments from the guaymas basin slope (central gulf of california): 250,000-year climate record.

During Deep Sea Drilling Project-International Program of Ocean Drilling leg 64, December 1978 to January 1979, the initial test of the Deep Sea Drilling Project's hydraulic piston corer obtained an almost undisturbed section from a 152-meter hole into the sediments of the oxygen minimum zone at a depth of 655 meters along the Guaymas slope in the central Gulf of California. The section records variations in climate, productivity, and circulation for more than 250,000 years of Late Pleistocene to Holocene history with recordings of seasonal variations in these parameters in the laminated sections.

Kinetics of the inactivation of human and bovine trypsins and chymotrypsins by alpha1-proteinase inhibitor and of their reactivation by alpha2-macroglobulin.

The time dependency of inactivation of human cationic trypsin and chymotrypsin II and of bovine trypsin and alpha-chymotrypsin by human serum has been investigated. Since the molar concentration of serum alpha1-proteinase inhibitor is much higher than that of other inhibitors, this time dependence could be used to calculate the rate constants kass for the association of alpha1-proteinase inhibitor with the four proteases. The association process was found to be second order, with kass ranging from 1 x10(4) s-1 (human trypsin) to 2.

[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats].

Sprague-Dawley rats are sensitive to the teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, but the dose of inhibitor necessary to induce the same rate of characteristic malformations is twice as large for Sprague-Dawley as for Wistar rats. This variation is probably related to differences in levels of blood cholesterol in the strains and demonstrates a relationship between teratogenicity and metabolic disturbances.

A kinetic study of the inhibition of human and bovine trypsins and chymotrypsins by the inter-alpha-inhibitor from human plasma.

Human plasma inter-alpha-inhibitor forms 1:1 inactive complexes with human and bovine trypsins (EC 3.4.21.

[Incorporation of 3H-thymidine in Wistar rat embryos treated with AY 9944].

Intake of tritiated thymidine by the embryos of Wistar pregnant rats treated by AY 9944 is significantly lowered. This decrease is parallel with the embryonic hypotrophy. Is there a causal relationship between the two phenomena?

LSD: no teratogenic action in rats, mice, and hamsters.

Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.

Aspects of the pharmacology of a new anthelmintic: pyrantel.

1. The pharmacological properties of an anthelmintic, pyrantel, and some of its analogues have been described and compared with piperazine in a variety of vertebrate and helminth preparations.2.