[Possible mechanisms of unilateral hippocampal insult after bilateral occlusion of common carotid arteries in rats with different types of behavior].

Possible mechanisms of unilateral ischemic insults in CA1 region of hippocampus and anterior dorsal nuclei of thalamus after bilateral occlusion of common carotid arteries in rats with different types of behavior are discussed.

[Interhemispheric asymmetry of the hippocampal damage after bilateral ligation of common carotid arteries].

Permanent bilateral occlusion of common carotid arteries in rats with different behaviour types led to non-uniform structural alterations in the hippocampus. In the majority of animals, morphological changes were diffuse (i.e.

[Structural changes in vestibular nuclei of macaca mulatta brain following flight in satellite Bion-11].

The structure of vestibular nuclei cells was studied in the brain of Macaca mulatta on return from the 14-d flight on satellite BION-11 and in 2 days of recovery. The monkey suddenly deceased on day 2 since landing because of aspiration asphyxia on completion of biopsy of muscle and bone tissues. Basic shifts in neural cells of the vestibular nuclei were focal tigrolysis and formation of larger clodlets by remains of tigroid.

Effects of black widow spider venom and latrocrustatoxin on crustacean nerve cells: electrophysiological and ultrastructural study.

1. Black widow spider venom (BWSV), or crustacean-specific toxin purified from it (named latrocrustatoxin, LCT) were lethal for the crayfish. 2.

[Individual differences in the reactions to acute stress related to behavioral types. The structural changes in the brain].

Structural alterations in the brain after stress were studied in rats with different behavior type in open field and forced swimming tests. The most typical brain reaction to acute stress was a combination of reactive (hypertrophy and fission of mitochondria, hyperplasia of rough reticulum) and destructive (disintegration of mitochondria and rough reticulum) alterations which were different in rats with various behavior types. Thus, in rats with the active type of behavior showing the greatest resistance to stress (see report 1) the reactive processes were more manifest, while the the rats with the passive type of behavior showing lower resistance to stress developed destructive processes.

[Effect of substance P on survival of rats after cerebral ischemia: the effect depends on behavior type].

In rats with different behaviour types in tests of "open field" and "forced swimming", influence of intraperitoneal administration of P-substance (PC) neuropeptide to survival and structural-metabolic changes in brain after double-sided ligating of carotid arteries. It was established that PC exerts different influence on stability to circulating cerebral hypoxia according to behaviour types: it increases stability in rats with passive behaviour type, decrease stability in rats with active behaviour type and does not influence on rats with middle behaviour type. Results shows the necessity of individual approach to peptide use with the view to increase stabilization to cerebral ischemia.

[Morphophysiologic study of reticulo-cortical pathways in the rabbit].

The character of functional connections between the midbrain reticular formation (RF) and the neocortex was studied in rabbits. Unit activity was recorded in sensorimotor cortex by extracellular microelectrode during RF stimulation. Short-latency neuronal reactions were found presumably identified as monosynaptic responses.

[Ultrastructure of the cerebral cortex of the rat during noise stress and alcoholic intoxication].

Ultrastructure of the rat sensomotor and acoustic cortex has been studied at a separate and joined effect of noise and alcoholic intoxication during 7 and 35 days. Certain changes in vessels, neural and glial cells specific for separate effect of noise and alcohol have been revealed. Combined application of noise and alcohol results in a more profound disorders in the cerebral vessels, with predominance of changes specific for alcoholic intoxication.

[Ultrastructure of the nuclei of neurons and glial cells of the cerebral cortex during experimental alcoholic intoxication].

Nuclear ultrastructure of neurons and glial cells of the rat sensomotor cortex was studied under chronic alcoholic intoxication. During 24 h the animals drank up about 10 ml of 20 degrees alcohol. In the course of prolonged alcoholic intoxication there occurred processes leading to deformation of the nuclei of neurons and glial cells and to the deficiency of nuclear and cytoplasmic substances.

[Effect of acoustic stress on morphology of rat sensorimotor cortex].

The structure and ultrastructure of the sensomotor cortex in pubertal rats were studied 7, 14 and 21 days after acoustic stress. Focal peripheral chromatolysis and pigment accumulation by lysosomes were found in neurons after 14 and 21 days of exposure to noise. The number of lysosomes in which pigment was accumulated, and multivesicular bodies appeared, increased in the glial cells.

[Neurono-glial changes in the cerebral cortex of animals exposed to white noise].

The rat acoustic cortex has been studied at light optic and ultrastructural levels under the white noise stimulation. After the noise stimulation for 7 days, micropunctate hemorrhages, proliferation and hypertrophy in cells of microglia and astrocytic glia are noted. After the noise stimulation for 21 days, the neuroglial reaction becomes less pronounced, there are no hemorrhages, a great amount of neurons with peripheral and total chromatolysis appear.

[Effect of white noise on the rat auditory cortex ultrastructure].

Changes in ultrastructure of neurones and glial cells of rat auditory cortex were studied after exposure to white noise for 21 days. Appearance of light neurones with peripheral chromatolysis and the increased number of lysosomes, pigment granules and vacuoles were recorded both in the neurones and glial cells. It is concluded that exposure to white noise in chronic experiments is the pathogenic factor which causes destruction in the neurons and glial cells of the auditory cortex.

[Morphofunctional changes in the synapses of the rabbit sensomotor cortex during the summation reflex].

Synapses of the sensorimotor cortex were studied during summation reflex in chronic experiments on rabbits. Structural changes in presynaptic and postsynaptic components of axodendritic synapses were revealed which are considered as an increase in the functional activity of the synaptic apparatus. The most pronounced response was observed in the postsynaptic matrix, which consisted in a considerable thickening of postsynaptic membranes in a number of axodendritic synapses.

[Structural and ultrastructural changes induced by angiotensin II in the cerebral cortex of animals].

Structure of capillaries, pericapillary glia and neurons of the sensomotor cerebral cortex was studied in rats after intraperitoneal injections of angiotensin-II (0.05 mg/kg of the body weight) administered once for 1, 3, 7, 14 and 21 days. The animals were decapitated 5 and 15 min after a single injection, and at repeated injections--15 min after the last one.

[Gliovascular changes in the rat central nervous system induced by angiotensin II].

The action of the synthetic polypeptide hormone angiotensin-II (A-II) on the ultrastructure of capillaries and perivascular glia of the cerebral cortex was studied in experiments on adult male rats. Intraperitoneal injections of the hormone are accompanied by swelling of the growing fibers and bodies of the precapillary glia (astrocytes), and by a strong narrowing of the capillary lumen. The endothelium of these vessels swells and layer inclusions appear in the cytoplasm of endothelial cells.

[Modeling cerebral dropsy (hydrocephalus) in animals by using angiotensin II].

The effect of a synthetic polypeptic hormone angiotensin-II on the structure of the brain ventricular system was studied in rats. A single injection of angiotensin-II, firm "Ciba", was given to rats in a dose of 0.05 mg/kg of body weight on the 1, 3, 7, 14 and 21st days.

[Ultrastructural changes in rabbit sensomotor cortex synapses following stimulation of the reticular formation].

Ultrastructural changes in the synapses of sensorimotor cortex caused by short and protracted stimulations of mid-brain reticular formation with single electric pulses were studied in rabbits. The observed submicroscopic shift in synaptic apparatus is regarded as a process of enhancing the activity of the sensorimotor synaptic apparatus with involvement of new interneuronal connections. Structural-functional changes in the synaptic apparatus occured at all levels of the sensorimotor cortex, with the predominance of this process at the upper level (layers I-IV); this is probably due to the greater representation of non-specific afferent endings in the upper cortical layers.

[Transformation of the synaptic apparatus of the rabbit sensorimotor cortex following creation of a polarization dominant].

Ultrastructural transformations of axo-somatic and axo-dendritic synapses of the rabbit sensorimotor cortex were studied during: 1) polarization of the cortical surface with a DC anode and 2) the setting up of a polarization motor dominant. A comparison between the structural characteristics of the examined region of the cerebral cortex of the two groups of animals revealed transformations in the synaptic apparatus, which may be regarded as a result of the formation of a temporary connection: an increase in the number of axo-dendritic synapses with considerably thickened postsynaptic membranes; an increase in the number of axonic terminals with a concentration of synaptic vesicles and mitochondria content. The indicated changes were more pronounced in the deep layers of the sensorimotor cortex.