Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-C Pyruvate MRSI.

This review article discusses the potential of hyperpolarized (HP) C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the signal-to-noise ratio for the identification of C-labeled metabolites, enabling dynamic and real-time imaging of the conversion of [1-C] pyruvate to [1-C] lactate and/or [1-C] alanine. The technique has shown promise in identifying upregulated glycolysis in most cancers, as compared to normal cells, and detecting successful treatment responses at an earlier stage than multiparametric MRI in breast and prostate cancer patients.

Quaternary E-W Extension Uplifts Kythira Island and Segments the Hellenic Arc.

Several crustal and lithospheric mechanisms lead to deformation and vertical motion of the upper plate during subduction, but their relative contribution is often enigmatic. Multiple areas of the Hellenic Forearc have been uplifting since Plio-Quaternary times, yet spatiotemporal characteristics and sources of this uplift are poorly resolved. The remarkable geology and geomorphology of Kythira Island, in the southwestern Hellenic forearc, allow for a detailed tectonic reconstruction since the Late Miocene.

Lithospheric flexure and rheology determined by climate cycle markers in the Corinth Rift.

Geomorphic strain markers accumulating the effects of many earthquake cycles help to constrain the mechanical behaviour of continental rift systems as well as the related seismic hazards. In the Corinth Rift (Greece), the unique record of onshore and offshore markers of Pleistocene ~100-ka climate cycles provides an outstanding possibility to constrain rift mechanics over a range of timescales. Here we use high-resolution topography to analyse the 3D geometry of a sequence of Pleistocene emerged marine terraces associated with flexural rift-flank uplift.

[Predictive value of Ages & Stages Questionnaires for cognitive performance at early years of schooling].

Unlabelled: The Ages and Stages questionnaires (ASQ) has been recently validated in our country for developmental screening. The objective of this study is evaluate the validity of ASQ to predict low cognitive performance in the early years of schooling.

Patients And Method: Diagnostic test studies conducted on a sample of children of medium-high socioeconomic level were evaluated using ASQ at least once at 8, 18 and/or 30 months old, and later, between 6 and 9 years old, reevaluated using the Wechsler Intelligence Scale for Children-third edition (WISC-III).

[Applicability of the Ages & Stages Questionnaires (ASQ) as a developmental screening tool for psychomotor delay].

The screening and timely intervention of developmental psychomotor delay (DSM) has proven benefits for the child, families and society. In order to improve the efficiency in the identification of these disorders, many scientific groups recommend performing clinical monitoring during health controls and the use of standard evaluations at specific patient age or when delays are suspected. In recent years, screening instruments have been developed based on the report of parents or primary caregivers, which have the advantage of being inexpensive, require little application and interpretation time and involve the adults who are responsible for the care and stimulation of the child.

The 2010 Mw 8.8 Maule megathrust earthquake of Central Chile, monitored by GPS.

Large earthquakes produce crustal deformation that can be quantified by geodetic measurements, allowing for the determination of the slip distribution on the fault. We used data from Global Positioning System (GPS) networks in Central Chile to infer the static deformation and the kinematics of the 2010 moment magnitude (M(w)) 8.8 Maule megathrust earthquake.

Seismic hazard in the Marmara Sea region following the 17 August 1999 Izmit earthquake.

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary slips at an average rate of 2-3 cm yr(-1), and historically has been the site of many devastating earthquakes.

Magnitude of late quaternary left-lateral displacements along the north edge of tibet.

Images taken by the earth observation satellite SPOT of the Quaternary morphology at 18 sites on the 2000-kilometer-long Altyn Tagh fault at the north edge of Tibet demonstrate that it is outstandingly active. Long-term, left-lateral strike-slip offsets of stream channels, alluvial terrace edges, and glacial moraines along the fault cluster between 100 and 400 meters. The high elevation of the sites, mostly above 4000 meters in the periglacial zone, suggests that most offsets resulted from slip on the fault since the beginning of the Holocene.

Epidemiology of gastric cancer in Chile. III. Diagnostic practices in Santiago, 1976-8.

The purpose of this paper is to estimate the validity of current diagnostic procedures used in Santiago, Chile, in identifying gastric cancer (GC) patients among people with gastric complaints, many of whom suffer possible premalignant conditions. Review of diagnoses on 2296 patients seen at the University Hospital during 1976 and 1977 revealed 103 confirmed cases of adenocarcinoma. This review permitted us to estimate the validity of clinical/radiological and endoscopic methods versus diagnosis made from pathological specimens.

Descriptive epidemiology of cancer in Chile: 1973-78.

Review of detailed Chilean cancer mortality data for 1973-78 reveals that gastric cancer overshadows all other sites, with Chile second in the world in age-adjusted mortality rate. An excess of male deaths is seen for all cancer sites combined except in 2 age groups, i.e.

Ecology of stomach cancer in Chile.

The results of a case-control study and one on nitrate ecology are summarized. Patients attending gastroscopy clinics in 8 participating hospitals in Santiago were interviewed before their diagnoses were known. Of these patients, 360 with stomach cancer were matched to those with noncancerous diseases who were selected from the pool, and we found that 1) patients lived in high-risk areas for longer periods in early life than did controls; 2) controls lived in low-risk areas for longer terms than did the patients; and 3) an association existed between stomach cancer and occupation in agriculture.

Epidemiology of gastric cancer in Chile: II - Nitrate exposures and stomach cancer frequency.

Nitrate levels in urine and nitrite levels in saliva were determined in school children 11-13 years of age in 2 areas of high stomach cancer mortality located in central Chile and in 2 areas of low stomach cancer mortality located at the extremes of Chile. Levels of both nitrates and nitrites were concurrently determined in selected vegetables obtained in these 4 study areas. Levels of nitrates were significantly higher in the urine of schoolchildren and in vegetables obtained from the northern low-risk area.

Epidemiology of gastric cancer in Chile: I - Case-control study.

The results of a case-control study of stomach cancer carried out with the collaboration of 7 participating hospitals in Santiago, Chile are reported. Patients attending gastroscopy clinics were interviewed before or after gastroscopy. The diagnosis was unknown to either the patient or the interviewer at the time of interview.

The epidemiology of cancer in Chile.

Despite the fact that cancer is underreported in most of Latin America, available data suggest that it is a major cause of death throughout the area. The most frequent sites among males are the stomach, lung, and prostate; among females, the cervix, stomach, and breast are affected most often. Only Cuba has a nationwide registry; Brazil, Colombia, and Peru have registries limited to areas.

Epidemiology of stomach cancer in Chile--the role of nitrogen fertilizers.

Chile ranks second in the world regarding age-adjusted mortality rates from stomach cancer. Analysis of death rates along its 25 provinces for a 15-year period (1957-1971) shows a peculiar geographic pattern of high and low-risk areas. Three agricultural provinces (Maule, Linares and Nuble, located south of Santiago), population 460,000, show a median rate of 50 x 1 per 100,000.