Gait temporal parameters estimation in toddlers using inertial measurement units: A comparison of 15 algorithms.

Background: Children's motor development can be evaluated through the analysis of gait temporal parameters and their variability. This requires the detection of gait events in a real-world environment, which can be achieved using inertial measurement units. Algorithms have been previously developed for healthy adults; however, the performance of these algorithms in the detection of gait events in toddlers has not been analysed.

Mean stability and between-session reliability of cycling biomechanics variables in elite pursuit cyclists.

The purpose of this study was to determine the number of crank revolutions required to obtain stable mean values of sagittal plane biomechanics variables, and the between-session reliability of these variables, whilst cyclists used an aerodynamic position. Eighteen elite cyclists completed a 3-min maximal bout on a cycling ergometer. Lower-limb kinematic and kinetic data were captured using 2D motion capture and force pedals.

Microwave-Energy-Based Device for the Treatment of Cellulite and Localized Adiposity: Recommendations of the "Onda Coolwaves" International Advisory Board.

The body contour market has grown rapidly in recent years, due to persistent requests for noninvasive treatments for localized fat adiposities, cellulite, and skin laxity. A variety of different methods are now available to improve body shaping. This review aims to provide an exhaustive compendium of the main recommendations for the optimal use of an innovative device delivering microwaves (MWs) for unwanted fat and cellulite reduction (Onda Coolwaves, DEKA, Florence, Italy), resulting from the experiences of the most expert international users.

New Concepts in Circumareolar Mastopexy: The "Star Interlocking Suture"-A Case Series.

The circumareolar approach is one of the most popular and versatile in breast surgeries. Nevertheless, this approach usually implies a closure under tension which could lead to areolar distortion, scar widening and hypertrophic scarring. To prevent these complications, different surgical adjustments to this technique have been proposed, such as the Hammond's "Interlocking Gore-Tex suture.

Evaluation of the Efficacy of the Combined Therapy of Botulinum Toxin and Hyaluronic Acid Compared to Conservative Intervention in the Treatment of Chronic Peripheral Facial Paralysis of Oncologic Etiology.

Background: Neoplasms in the head and neck often lead to peripheral facial paralysis (PFP), impacting facial expression and causing psychological distress. Standard treatments involve physiotherapy, but botulinum toxin type A (BTA) and hyaluronic acid (HA) injections have shown promise in promoting facial symmetry.

Aim: To assess the effectiveness of combined BTA and HA intervention in PFP patients, comparing it to conventional treatment (physiotherapy).

Effects of Nanofat and PRP on Type I Collagen Production in Striae Distensae: Preliminary Findings from a Prospective, Randomized Single-Blind Study.

Introduction: Striae distensae (SD) appear clinically as parallel striae, lying perpendicular to the tension lines of the skin. SD evolve into two clinical phases, an initial inflammatory phase in which they are called "striae rubrae" (SR) and a chronic phase in which they are called striae albae (SA). This study investigates the synergistic effect of nanofat and platelet-rich plasma (PRP) injections on collagen production in fibroblasts derived from SA (SAF).

The Role of the Plasminogen Activator Inhibitor 1 ( ) in Ovarian Cancer: Mechanisms and Therapeutic Implications.

Ovarian cancer (OC) is one among most significantly fatal gynecological cancers, with late-stage detection and an inadequate prognosis. Plasminogen activator inhibitor-1 ( ) gene anticipates negative outcomes in many different kinds of malignancies. Several research investigations are currently being done to examine the biological role of in OC and the possible benefits of targeted pharmacotherapies.

Increased levels of versican and insulin-like growth factor 1 in peritumoral mammary adipose tissue are related to aggressiveness in estrogen receptor-positive breast cancer.

The adipose tissue (AT) surrounding breast cancer (BC) plays a pivotal role in cancer progression and represents an optimal source for new biomarker discovery. The aim of this work was to investigate whether specific AT factors may have prognostic value in estrogen receptor-positive (ER+) BC. Proteoglycan Versican (VCAN), Insulin-like Growth Factor 1 (IGF1), Reticulon 4B (RTN4), chemokines CCL5 (also known as RANTES) and interleukin 8 (IL-8) are expressed in AT and may play important roles in BC progression.

Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells.

An established hallmark of cancer cells is metabolic reprogramming, largely consisting in the exacerbated glucose uptake. Adipocytes in the tumor microenvironment contribute toward breast cancer (BC) progression and are highly responsive to metabolic fluctuations. Metabolic conditions characterizing obesity and/or diabetes associate with increased BC incidence and mortality.

Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study.

Objectives: To evaluate the feasibility and acceptability of a primary care-based intervention for improving post-diagnostic dementia care and support (PriDem), and implementation study procedures.

Design: A non-randomised, mixed methods, feasibility study.

Setting: Seven general practices from four primary care networks (PCNs) in the Northeast and Southeast of England.

Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention.

Objectives: Provision of personalised care planning is a national priority for people with dementia. Research suggests a lack of quality and consistency of care plans and reviews. The PriDem model of care was developed to deliver feasible and acceptable primary care-based postdiagnostic dementia care.

Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis).

Background: Yerba mate (YM, Ilex paraguariensis) consumption beneficially affects the bones. However, whether YM components exert their effect on bone cells directly remains elusive.

Methods: We evaluated how main YM components affect osteoblastic (MC3T3-E1) and osteocytic (MLO-Y4) cells in vitro when administered separately or in an aqueous extract.

A Combined Experimental/Computational Study of Dicationic Ionic Liquids with Bromide and Tungstate Anions.

A panel of dicationic ionic liquids (DILs) with different rigid xylyl (ortho, meta, para) spacers and different anions (bromide and tungstate) has been synthetised and characterised through different experimental and computational techniques. Differences and analogies between the systems are analysed using information derived from their DFT structures, semiempirical dynamics, thermal behaviour, and catalytic properties versus the well-known reaction of CO added to epichlorohydrin. A comparison between the proposed systems and some analogues that present non-rigid spacers shows the key effect displayed by structure rigidity on their characteristics.

Bioactive Dressing: A New Algorithm in Wound Healing.

Wound management presents a significant global challenge, necessitating a comprehensive understanding of wound care products and clinical expertise in selecting dressings. Bioactive dressings (BD) represent a diverse category of dressings, capable of influencing wound healing through various mechanisms. These dressings, including honey, hyaluronic acid, collagen, alginates, and polymers enriched with polyhexamethylene biguanide, chitin, and chitosan derivatives, create a conducive environment for healing, promoting moisture balance, pH regulation, oxygen permeability, and fluid management.

Long-term outcomes and future challenges in face transplantation.

Face transplant (FT) has emerged as a groundbreaking option for patients with severe facial deformities, resulting from congenital disorders, trauma, or tumor ablation. Although reconstructive surgery has made significant strides, the challenges of restoring both form and function remain, particularly in centrally located defects. This review explored the long-term outcomes of FT, addressing its challenges and potential pitfalls.

Effect of corticosteroids on ischemia-reperfusion injury of deep inferior epigastric perforator flap after re-exploration for anastomosis thrombosis: A prospective randomized trial.

Patients undergoing breast reconstruction with the deep inferior epigastric perforator (DIEP) flap are at risk of arterial and venous thrombosis, necessitating flap salvage surgery. However, this carries the risk of ischemia-reperfusion injury (IRI) and potential significant partial or complete flap loss. The objective of this study was to evaluate the potential benefit of corticosteroids in reducing IRI related complications in DIEP flaps that are returned to the operation theater for attempted salvage after venous or arterial failure.

Snip conjunctivoplasty associated with methylene blue staining for treatment of postoperative conjunctival chemosis.

Conjunctival chemosis usually undergoes spontaneous resolution; sometimes, it requires treatment. We present the case of a 43 years-old female patient who developed bilateral conjunctival chemosis following upper and lower blepharoplasty. Two months after the operation, patient underwent bilateral snip conjunctivoplasty with methylene blue demarcation of the chemotic conjunctiva.

Assessment of deep plane facelift combined with fascia lata graft for the static treatment of facial palsy: A preliminary report.

Addressing facial palsy (FP) presents intricate challenges in achieving natural expressions. Although free functional muscle transfers (FFMT) offer effective smile restoration, age impacts their efficacy. The optimal FFMT age range of 5-55 years is limited by physical fitness, which extends beyond age boundaries.

Can inertial measurement unit sensors evaluate foot kinematics in drop foot patients using functional electrical stimulation?

The accuracy of inertial measurement units (IMUs) in measuring foot motion in the sagittal plane has been previously compared to motion capture systems for healthy and impaired participants. Studies analyzing the accuracy of IMUs in measuring foot motion in the frontal plane are lacking. Drop foot patients use functional electrical stimulation (FES) to improve walking and reduce the risk of tripping and falling by improving foot dorsiflexion and inversion-eversion.

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.

Objectives: The aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings obtained from studies in patients with apathy in different forms of dementia, including Alzheimer's disease (AD), vascular (VaD) and mixed dementia, frontotemporal dementia (FTD), and Parkinson's disease dementia (PDD).

Methods: Randomized controlled trials, non-randomized controlled trials, controlled before-after studies, and interrupted time series from four databases (WebOfScience, Scopus, Pubmed, and PsycINFO) addressing apathy in adults or older people aged over 65 years of age affected by dementia were included.

Results: The prevalence of apathy was 26-82% for AD, 28.

Betaine mediated enhancement of thermal stability and acidity tolerance of vanadium(V) solutions.

A panel of novel vanadium(IV)-betaine complexes has been synthesized according to new and efficient methodologies and characterized through both spectroscopic techniques and thermal analyses. Vanadium(IV)-betaine solutions have been electrochemically oxidized and the effect of betaine ligands on the thermal and pH stability of vanadium(V) solutions has been evaluated under different temperature and acidity conditions. The obtained results displayed a remarkable effect for both of the examined parameters, achieving the preparation of aqueous vanadium(V) solutions displaying long term stability at more than 55 °C under mild acidic conditions.