Management of infants presenting with fever: a review of pan-London hospital guidelines and national guidelines.

Febrile infants often have self-limiting conditions. Differentiating them from infants with serious bacterial infections can be challenging. We aimed to understand how febrile infants are managed across London, by analysing the management steps from local clinical practical guidelines (CPGs) and comparing them to the national guideline 143 (NG143).

Real-World Experience in Tricuspid Transcatheter Edge-to-Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry.

Background: Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real-world data might improve patient selection and outcome.

Consistent Interpretation of Time- and Frequency-Domain Traces of Ion Migration in Perovskite Semiconductors.

The migration of mobile ions through the metal halide perovskite layer is still one of the main reasons for the poor stability of perovskite solar cells, LEDs, and photodetectors. To characterize mobile ions in the perovskite layer, time- and frequency-based electrical measurements are promising techniques. However, the presence of transport layers complicates their interpretation, limiting the information about mobile ions that can be extracted, and it is not clear how different features in frequency- and time-domain measurements relate to mobile ions.

Case series of kidney transplantation in two pediatric recipients with rare genetic diseases and intellectual disability.

Background: Kidney transplantation is the gold standard treatment for end-stage kidney disease in children. Rare genetic systemic diseases associated with cystic kidney disease such as COL4A1-related disorder and oral facial digital syndrome type 1 could contribute to end-stage kidney disease in the pediatric population but there is scarce evidence in the literature regarding kidney transplant outcomes in these cases.

Case Presentation: We report a case of a 5-year-old male with COL4A1-related disorder who received a living-related donor kidney transplant from his mother.

Engaging grade school learners with an interactive medical imaging activity.

This case report describes a 45-min active learning lesson plan that engages 4th-5th and 6th-8th grade school students in spatial reasoning through a review of medical imaging. The lesson plan reviews different planar orientations and cross-sections of computed tomography (CT) images of familiar objects. The lesson is designed to introduce students to the idea that scientists are key contributors to healthcare, including in medical imaging technologies that facilitate the visualization of internal structures of patients without invasive procedures.

JAK2 p.R564 germ line variants associated with hereditary thrombocythemia and hematologic neoplasms.

The Janus kinase 2 (JAK2) V617F mutation activates the transcription pathway and has been well-characterized as a driver of myeloproliferative neoplasms (MPNs). Recently, there has been a heightened interest in understanding germline predisposition to hematological malignancies including MPN, including several reports of familial MPN. Here, we retrospectively analyzed medical records and data from genetic testing to describe twelve patients with germline variants at amino acid position 564 of JAK2.

Hirudotherapy Efficacy and Complications in the Management of Microsurgical Breast Reconstruction: A Systematic Review.

Background: We aimed to assess the effect of hirudotherapy on flap congestion and thrombosis in adult female patients who underwent microvascular breast reconstruction.

Methods: A systematic review of PubMed, Web of Science, and Cochrane was completed. A qualitative synthesis of all included studies was then performed.

Generalizability of consensus regarding standardized letters of evaluation competitiveness: A validity study in a national sample of emergency medicine faculty.

Background: Standardized letters of evaluation (SLOEs) are an important part of residency recruitment, particularly given the limited availability of other discerning factors in residency applications. While consensus regarding SLOE competitiveness has been studied within a small group of academic faculty, it remains unexplored how a more diverse group of letter readers interpret SLOEs in terms of competitiveness.

Methods: A sample of 50 real SLOEs in the new SLOE format (2022 eSLOE 2.

Rise of the machines: Normothermic regional perfusion use in heart transplantation in the United States.

Background: Normothermic regional perfusion (NRP) and direct procurement and perfusion (DPP) allow for transplantation with donation after circulatory death (DCD) hearts. This study aimed to characterize the use of and variations in NRP and DPP for DCD transplants in the United States.

Methods: Heart transplants performed between December 1, 2019 and March 31, 2024, were identified from the United Network for Organ Sharing database.

Development and validation of genome-informed and multigene-based qPCR and LAMP assays for accurate detection of : a critical quarantine pathogen threatening the potato industry.

one of the most aggressive pectinolytic phytopathogens, causes blackleg disease in potatoes, resulting in significant economic losses and adversely impacting one of the world's most important food crops. The diagnostics methods are critical in monitoring the latent infection for international trade of potato seed tubers and in implementation of control strategies. Our study employed a whole-genome comparative approach, identifying unique target gene loci (LysR and TetR family of transcriptional regulators gene regions) and designing loop-mediated isothermal amplification (LAMP) and a multi-gene-based multiplex TaqMan qPCR assays for specific detection and differentiation of .

ChatG-PD? Comparing large language model artificial intelligence and faculty rankings of the competitiveness of standardized letters of evaluation.

Background: While faculty have previously been shown to have high levels of agreement about the competitiveness of emergency medicine (EM) standardized letters of evaluation (SLOEs), reviewing SLOEs remains a highly time-intensive process for faculty. Artificial intelligence large language models (LLMs) have shown promise for effectively analyzing large volumes of data across a variety of contexts, but their ability to interpret SLOEs is unknown.

Objective: The objective was to evaluate the ability of LLMs to rate EM SLOEs on competitiveness compared to faculty consensus and previously developed algorithms.

Interventions to reduce burnout in emergency medicine: a national inventory of the Canadian experience to support global implementation of wellness initiatives.

Burnout in healthcare workers is a global issue, with Emergency Medicine (EM) particularly impacted. Many countries have tried implementing wellness initiatives to reduce burnout and improve wellness. This paper summarizes interventions implemented in Canada to-date with the aim of supporting the design of wellness interventions in EDs globally.

Diversification of signal identity and modus operandi of the Haemophilus influenzae PAS-less ArcB sensor kinase.

Bacteria employ two-component signal transduction systems (TCS) to sense environmental fluctuations and adjust their cellular functions. The Arc TCS is crucial for facultative anaerobes as it enables adaptation to varying respiratory conditions. The Escherichia coli ArcB detects redox changes through two cysteine amino acid residues within its PAS domain.

Artificial Intelligence in Human Reproduction.

The use of artificial intelligence (AI) in human reproduction is a rapidly evolving field with both exciting possibilities and ethical considerations. This technology has the potential to improve success rates and reduce the emotional and financial burden of infertility. However, it also raises ethical and privacy concerns.

Socioeconomic, Demographic, and Clinical Factors Associated with Postpartum Readmission.

To determine if socioeconomic, demographic, and clinical characteristics are associated with postpartum readmission. A retrospective cohort study evaluating all pregnant patients that delivered at seven hospitals within a large academic health system in New York between January 1, 2018 and March 1, 2020. Demographic information, medical comorbidities, and characteristics of antepartum, intrapartum, and postpartum care were compared between patients who were readmitted within 6 weeks postpartum and those who were not.

Educational technology to support patient safety in the operating room: clinical simulation guides.

to develop and validate two clinical simulation guides to support and disseminate a culture of safety in the surgical environment. methodological study supported by the International Nursing Association for Clinical Simulation and Learning theoretical framework. The snowball technique was used to validate the clinical guidelines with experts on the subject.

"I am putting my fear on them subconsciously": a qualitative study of contraceptive care in the context of abortion bans in the U.S.

Background: Since the Dobbs vs. Jackson Women's Health Organization decision in June 2022, providers throughout the U.S.

sp. nov., pectinolytic bacterium isolated from pineapple ().

Recently, species clustering within has been identified as complex, encompassing validly published names, including and , with some strains potentially delineating new species. In this study, genomes of strains isolated from a bacterial heart rot outbreak in pineapple ( var. ) on Oahu, Hawaii, along with two strains from pineapple in Malaysia, were sequenced.

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma.

NK cells offer a promising alternative to T cell therapies in cancer. We evaluated IPH6501, a clinical-stage, tetraspecific NK cell engager (NKCE) armed with a non-alpha IL-2 variant (IL-2v), which targets CD20 and was developed for treating B cell non-Hodgkin lymphoma (B-NHL). CD20-NKCE-IL2v boosts NK cell proliferation and cytotoxicity, showing activity against a range of B-NHL cell lines, including those with low CD20 density.

Indications of digital literacy during Latino-focused, community-based COVID-19 testing implementation.

Objective: We sought to characterize indicators of digital literacy among persons testing for COVID-19 and community health workers (CHWs) providing testing via a digital platform in low-income, majority-Latino communities in California.

Materials And Methods: From March 2021 to March 2022, we trained CHWs to provide community-based COVID-19 testing that relied on a digital platform for registration, recording and reporting of results. Among community members, we examined factors associated with accessing test results digitally and time to results receipt.