[The action of infrasound oscillations on the properties of water and of a DNA solution].

The effect of mechanical vibrations (MV) electrical conductivity of water and optical density of aqueous DNA solution. Distilled water was treated with MV of several frequencies from 3 to 5000 Hz with an intensity of 90 dB for 30 minutes. Different sensitivities of water specific electrical conductivity (SEC) were determined (the value of distilled water SEC was 209 +/- 2 microS/m).

[Effect of mechanical oscillations in physiological solution on the contractile activity of the snail heart].

The effect of perfusate on the contractile activity of an isolated internally perfused heart of Helix pomatia was studied. The changes in heart activity induced by the switching of the perfusate stream were more pronounced in a potassium-free solution when the Na+, K(+)-pump was inactivated. It was found that the decrease in the amplitude of contractions of snail heart by acetylcholine (5.

[Early application of angiotensin converting enzyme inhibitors in acute myocardial infarction].

Inhibitors of angiotensin converting enzyme (ACE) were tried in patients early after myocardial infarction (MI) irrespective of the severity of circulation insufficiency. Monopril was used in 23 patients in the dose 7.6 mg/day.

[The clinical and prognostic information value of painless myocardial ischemia in the early postinfarct period].

A study was made of painless myocardial ischemia in the early postinfarction period (day 14) in order to define its influence on the clinical course and immediate prognosis. 25 patients aged 32 to 60 years with acute primary myocardial infarction were examined. 17 patients had large-focal and 8 small-focal infarction.

[Effect of anaprilin on the tyrosine hydroxylase activity of the oral mucosa in dogs with experimental stomatitis].

It was shown that in dogs with experimental aphthous stomatitis (ligation of the common bile duct) tyrosine hydroxylase activity and content of catecholamines (CA) in the oral mucosa were increased. Blockade of beta-adrenoreceptors caused by anaprilin (1 mg/kg) led to the further increase of tyrosine hydroxylase activity. A relative decrease of CA content was simultaneously observed.

[Changes in the blood microcirculation in the mouth mucosa in experimental stomatitis].

Aphthous lesions in the oral mucosa (OM) were simulated in dog experiments by ligation of the common bile duct. In one of the experimental groups the beta-adrenoblocker propranolol was administered 30 min before surgery. Two hours after surgery the animals manifested changes in blood microcirculation of the OM.

[Possibilities of using neurotropic agents for preventing the development of aphthous stomatitis].

Aphthous lesions of the oral mucosa were simulated in dogs by common bile duct ligation. In one of the experimental groups, the animals were administered the beta-adrenoblocker obsidan 30 min before operation. Two hours after operation the regions of the oral mucosa mostly affected by aphthous lesions were examined for the content of adrenaline and noradrenaline (NA).

[Structuro-functional changes in lymphoid populations during the course of carcinogenesis].

A comparative study was made of the percentage of cells bearing the receptor for the third component of the complement (LRC) and of the total cell content in the rat lymphoid organs as related to the time course of cancerogenesis. It was shown that impairment of the maturation processes in the thymus and in the peripheral organs (lymph nodes, blood) of the immunocompetent systems produces changes in intercellular interactions, reflected by accumulation of B cells, i. e.

[Analysis of the effect of morphine on the reproductive capacity and immunological status of mice].

Embryogenesis process is disturbed under the action of prolonged morphine administration to CBA mice. Simultaneously a decrease in the level of antibody-synthesizing cells and a significant reduction in the cooperating interaction of T and B lymphocytes in response to the injection of sheep red blood cells are noted. At the same time stimulation of bone marrow cells and specific sensitization of MIF-inducers to the antigen from the brain of morphinized mice are revealed.

[Use of the enzyme neuraminidase for immunotherapeutic treatment of chemically induced carcinogenesis].

The effect of vibrio cholerae neuraminidase (VCN) on the growth of dimethylbenzanthracene-induced sarcoma cells in the inbred CBA mice was investigated. The use of this preparation was started after the appearance of the tumour. Injection of 50 units of VCN twice a week for three months was effective at the early stages of carcinogenesis.

[Changes in the immunologis status of the body during carcinogenesis detected by the physico-chemical characteristics of cells of the immunocompetent system].

The state of cell population of the lymph nodes and the thymus was studied on a model of rat sarcoma of the hip(induced by dimethlbenzanthracene) by the method of fluorescent sounds. Statistically significant changes of incorporation of the negatively charged sound 1-anilino-8-naphthalinosulfonate (ANS) into cell suspension, depending on the stage of sarcoma development, were detected. The appearance of cell forms with a lesser hydrophobic character of the surface and with less binding points for the ANS were noted at the early carcinogenesis periods.

[Enzymatic and immunologic activity of lymphocytes during chemical carcinogenesis].

The activity of acid phosphatase and some dehydrogenases in the peripheral blood lymphocytes was compared with the development of cell immunity, assessed by the macrophage migration inhibition test, during chemical carcinogenesis in Wistar rats. At the early stages of the carcinogenesis the changes of the enzymatic activities of succinic dehydrogenase and acid phosphatase proved to coordinate with a sufficiently high level of the immunological reactivity of the cell type in 66% of the animals. With the progressive growth of the tumours there occurred a disturbance of the enzymatic balance in the lymphoid cells and a simultaneous decrease in the immunological response.