Nanoparticles of nucleotide-free analogue of vitamin B formed in protein nanocarriers and their neuroprotective activity in vivo.

Recently, we have described the first supermolecular nanoentities of vitamin B derivative, viz. monocyano form of heptabutyl cobyrinate, unique nanoparticles with strong noncovalent intermolecular interactions, emerging optical and catalytic properties. Their nearest analogue, heptamethyl cobyrinate (ACCby), exhibits bioactivity.

Effect of Magnetic Impurities on Superconductivity in LaH.

Polyhydrides are a novel class of superconducting materials with extremely high critical parameters, which is very promising for sensor applications. On the other hand, a complete experimental study of the best so far known superconductor, lanthanum superhydride LaH , encounters a serious complication because of the large upper critical magnetic field H (0), exceeding 120-160 T. It is found that partial replacement of La atoms by magnetic Nd atoms results in significant suppression of superconductivity in LaH : each at% of Nd causes a decrease in T by 10-11 K, helping to control the critical parameters of this compound.

'Phantom' atoms and thermal motion in fullerene Crevealed by x-ray and neutron diffraction.

The additional atomic occupancy in the octahedral and the tetrahedral voids of the face-centered cubic lattice (fcc) of fullerene Cwas detected by neutron and x-ray powder diffraction. The observed occupancy exactly tracks the rearrangement of the orientation order with temperature decreases and results from the large atomic vibrations of the carbon atoms constituting the fullerene molecules. This motion assumes a small but finite probability to find the carbon atoms in the fcc interstitial voids, which is modeled by the detected 'phantom' occupancies.

Transformation of diamond to fullerene-type onions at pressure 70 GPa and temperature 2400 K.

We report the observation of a phase transition of diamond to denser than diamond carbon phase composed from 2 to 3 fullerene-type shells of onions. Raman spectra indicate the fullerene-type of the onions shells. The onions phase is a stable phase in a diamond instability zone of a phase diagram of carbon at pressure 70 GPa and temperature 2400 K.

A cohabiting bacterium alters the spectrum of short RNAs secreted by Escherichia coli.

Recently, it has been found that bacteria secrete short RNAs able to affect gene expression in eukaryotic cells, while certain mammalian microRNAs shape the gut microbiome altering bacterial transcriptome. The involvement of bacterial RNAs in communication with other bacteria is also expected, but has not been documented yet. Here, we compared the fractions of extremely short (12-22 nucleotides) RNAs secreted by Escherichia coli grown in a pure culture and jointly with bacteria of the Paenibacillus genus.

[Influence of embient air pollution by automobile transport on malignancies development in population of Kemerovo city].

To reveal relationship between automobile transport emissions and oncologic morbidity among Kemerovo population, the authors selected crossroads and parts of highways with intense traffic. Two groups were observed among the residents of houses near the main crossroads and along highways. As a reference group, residents of houses distant from highways were selected.

Supervised extensions of chemography approaches: case studies of chemical liabilities assessment.

Chemical liabilities, such as adverse effects and toxicity, play a significant role in modern drug discovery process. In silico assessment of chemical liabilities is an important step aimed to reduce costs and animal testing by complementing or replacing in vitro and in vivo experiments. Herein, we propose an approach combining several classification and chemography methods to be able to predict chemical liabilities and to interpret obtained results in the context of impact of structural changes of compounds on their pharmacological profile.

Towards in silico identification of the human ether-a-go-go-related gene channel blockers: discriminative vs. generative classification models.

HERG potassium channels have a critical role in the normal electrical activity of the heart. The blockade of hERG channels in heart cells can result in a potentially fatal disorder called long QT syndrome. HERG channels can be blocked by compounds with diverse structures belonging to several drug classes.

Zero-differential resistance state of two-dimensional electron systems in strong magnetic fields.

We report the observation of a zero-differential resistance state (ZDRS) in response to a direct current above a threshold value I>I th applied to a two-dimensional system of electrons at low temperatures in a strong magnetic field. Entry into the ZDRS, which is not observable above several Kelvins, is accompanied by a sharp dip in the differential resistance. Additional analysis reveals an instability of the electrons for I>I th and an inhomogeneous, nonstationary pattern of the electric current.

Hybrid phosphorescence and fluorescence native spectroscopy for breast cancer detection.

Fluorescence and phosphorescence measurements are performed on normal and malignant ex vivo human breast tissues using UV LED and xenon lamp excitation. Tryptophan (trp) phosphorescence intensity is higher in both normal glandular and adipose tissue when compared to malignant tissue. An algorithm based on the ratio of trp fluorescence intensity at 345 nm to phosphorescence intensity at 500 nm is successfully used to separate normal from malignant tissue types.

[Assessing the risk of lead environmental pollution for children's health status in Russia].

The calculations prove that average serum lead level in children residents of cities with low environmental lead content approximates 10 mg/dl. This value in cities with high environmental lead content could be nearly 2 times higher and equals 18.9 mg/dl.

[Experience in the study of the effects of lead on the health status of children in Belovo].

Lead releases in Belovo town containing metallurgy enterprise had reached 120 tons/year earlier, but in recent years have decreased to 9 tons/year. Reduction of the production induced decrease of lead levels in the ambient air from 0.7-2.

[Hormonal profile in chronic pain syndromes of somatogenic etiology].

The integral "profile" of the groups of inpatients suffering from somatogenic chronic painful syndromes was plotted on a material of a comprehensive study into central and peripheral hormones, the total content, and correlations. Enkephalins are shown to play the integrating part in the development of stress-algogenic reactions.

[Disorder in the ratio of cortisol and insulin secretion in peptic ulcer and following vagotomy].

It was established that non-operated patients with duodenal ulcer and patients after organ-saving operations associated with vagotomy show an essential increase of insulin and cortisol secretion and reveal a strict dependence of hormonal secretion on the severity of the pathological process and time after operation. The increased cortisol/insulin ratio correlated with a reduction of the body mass of patients.

[Seasonal changes in the regulatory systems in duodenal ulcer].

Examinations of different patients with duodenal ulcer performed during one year revealed seasonal changes in the function of the regulatory systems. Secretion of histamine, serotonin, insulin, and hydrocortisone was increased in spring and reduced in autumn. Secretion of adrenalin, noradrenalin and acetylcholinesterase activity were high in summer and low in autumn.