Injectable Shear-Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations.

Sac embolization of abdominal aortic aneurysms (AAAs) remains clinically limited by endoleak recurrences. These recurrences are correlated with recanalization due to the presence of endothelial lining and matrix metalloproteinases (MMPs)-mediated aneurysm progression. This study incorporated doxycycline (DOX), a well-known sclerosant and MMPs inhibitor, into a shear-thinning biomaterial (STB)-based vascular embolizing hydrogel.

Polypharmacy and cumulative anticholinergic burden in older adults hospitalized with fall.

Introduction: Polypharmacy is a growing phenomenon associated with adverse effects in older adults. We assessed the potential confounding effects of cumulative anticholinergic burden (ACB) in patients who were hospitalized with falls.

Methods: A noninterventional, prospective cohort study of unselected, acute admissions aged ≥ 65 years.

Interaction with bioligands and in vitro cytotoxicity of a new dinuclear dioxido vanadium(V) complex.

One centrosymmetric bis(μ-oxido)-bridged vanadium(V) dimer with molecular formula [(VO)(pedf)] (1) has been synthesized from the reaction of VOSO·5HO with a Schiff base ligand (abbreviated with pedf) obtained from 2-acetylpyridine and 2-furoic hydrazide in methanol. Complex 1 was characterized by elemental analysis, UV-visible (UV-Vis), Fourier-transform infrared spectra (FT-IR), cyclic voltammetry (CV), electron paramagnetic resonance spectroscopy (EPR) and electrospray ionization-mass spectrometry (ESI-MS) techniques along with single crystal X-ray diffraction (SCXRD). The FT-IR spectral data of 1 indicated the involvement of oxygen and azomethine nitrogen in coordination to the central metal ion.

Symmetry and Higher-Order Exceptional Points.

Exceptional points (EPs), at which both eigenvalues and eigenvectors coalesce, are ubiquitous and unique features of non-Hermitian systems. Second-order EPs are by far the most studied due to their abundance, requiring only the tuning of two real parameters, which is less than the three parameters needed to generically find ordinary Hermitian eigenvalue degeneracies. Higher-order EPs generically require more fine-tuning, and are thus assumed to play a much less prominent role.

Analysis of recently duplicated TYRP1 genes and their effect on the formation of black patches in Oujiang-color common carp (Cyprinus carpio var. color).

Tyrp1 gene, as a member of the tyrosinase family, has undergone a recent duplication event during fourth-round whole genome duplication in common carp. In this research, three Tyrp1 genes were identified in Oujiang-color common carp (Cyprinus carpio var. color).

Cross-Diagnostic Validity of the Congenital Glaucoma Caregiver's Quality of Life Questionnaire (CarCGQoL).

Purpose: The Caregiver's Congenital Glaucoma QoL (CarCGQoL) questionnaire was proposed as a measure of QoL of caregivers with children with primary congenital glaucoma (PCG). Support for its psychometric properties among other diagnostic groups is required for scores to be interpreted in the same manner across groups. Therefore we investigated the measurement properties and cross-diagnostic validity of the CarCGQoL questionnaire among caregivers of children with congenital cataract, retinopathy of prematurity (ROP), and blinding corneal disorders.

Variance of the energy of a quantum system in a time-dependent perturbation: Determination by nonadiabatic transition probabilities.

For a quantum system in a time-dependent perturbation, we prove that the variance in the energy depends entirely on the nonadiabatic transition probability amplitudes b(t). Landau and Lifshitz introduced the nonadiabatic coefficients for the excited states of a perturbed quantum system by integrating by parts in Dirac's expressions for the coefficients c (t) of the excited states to first order in the perturbation. This separates c (t) for each state into an adiabatic term a (t) and a nonadiabatic term b (t).

A K-arylacetylide complex for catalytic terminal alkyne functionalization using KOBu as a precatalyst.

Herein we report a transition metal free catalytic terminal alkyne functionalization across the C-X triple bond (X = CH and N) with E-selective homo (alkyne-alkyne) and head-to-tail selective hetero (alkyne-nitrile) dimerization. A series of stoichiometric reactions enabled us to crystallize a reactive organometallic intermediate K-arylacetylide complex which was characterized by X-ray crystallography, indicating that an ionic mechanism is operative.

Nonadiabatic transition probabilities in a time-dependent Gaussian pulse or plateau pulse: Toward experimental tests of the differences from Dirac's transition probabilities.

For a quantum system subject to a time-dependent perturbing field, Dirac's analysis gives the probability of transition to an excited state |k⟩ in terms of the norm square of the entire excited-state coefficient c(t) in the wave function. By integrating by parts in Dirac's equation for c(t) at first order, Landau and Lifshitz separated c (t) into an adiabatic term a (t) that characterizes the gradual adjustment of the ground state to the perturbation and a nonadiabatic term b (t) that depends explicitly on the time derivative of the perturbation at times t' ≤ t. Landau and Lifshitz stated that the probability of transition in a pulsed perturbation is given by |b(t)|, rather than by |c(t)|.

Quantum transition probabilities during a perturbing pulse: Differences between the nonadiabatic results and Fermi's golden rule forms.

For a perturbed quantum system initially in the ground state, the coefficient c(t) of excited state k in the time-dependent wave function separates into adiabatic and nonadiabatic terms. The adiabatic term a(t) accounts for the adjustment of the original ground state to form the new ground state of the instantaneous Hamiltonian H(t), by incorporating excited states of the unperturbed Hamiltonian H without transitions; a(t) follows the adiabatic theorem of Born and Fock. The nonadiabatic term b(t) describes excitation into another quantum state k; b(t) is obtained as an integral containing the time derivative of the perturbation.

Purification and Characterization of a Novel Intracellular Sucrase Enzyme of Leishmania donovani Promastigotes.

The promastigote stage of Leishmania resides in the sand fly gut, enriched with sugar molecules. Recently we reported that Leishmania donovani possesses a sucrose uptake system and a stable pool of intracellular sucrose metabolizing enzyme. In the present study, we purified the intracellular sucrase nearly to its homogeneity and compared it with the purified extracellular sucrase.

Experimental and theoretical investigation of a mesoporous K(x)WO3 material having superior mechanical strength.

Mesoporous materials with tailored properties hold great promise for energy harvesting and industrial applications. We have synthesized a novel tungsten bronze mesoporous material (K(x)WO3; x ∼ 0.07) having inverse FDU-12 type pore symmetry and a crystalline framework.

Accurate, fully-automated NMR spectral profiling for metabolomics.

Many diseases cause significant changes to the concentrations of small molecules (a.k.a.

Radio frequency cavity analysis, measurement, and calibration of absolute Dee voltage for K-500 superconducting cyclotron at VECC, Kolkata.

Variable Energy Cyclotron Centre has commissioned a K-500 superconducting cyclotron for various types of nuclear physics experiments. The 3-phase radio-frequency system of superconducting cyclotron has been developed in the frequency range 9-27 MHz with amplitude and phase stability of 100 ppm and ±0.2(0), respectively.

Adiabatic and nonadiabatic contributions to the energy of a system subject to a time-dependent perturbation: complete separation and physical interpretation.

When a time-dependent perturbation acts on a quantum system that is initially in the nondegenerate ground state ∣0> of an unperturbed Hamiltonian H(0), the wave function acquires excited-state components ∣k> with coefficients c(k)(t) exp(-iE(k)t/ℏ), where E(k) denotes the energy of the unperturbed state ∣k>. It is well known that each coefficient c(k)(t) separates into an adiabatic term a(k)(t) that reflects the adjustment of the ground state to the perturbation--without actual transitions--and a nonadiabatic term b(k)(t) that yields the probability amplitude for a transition to the excited state. In this work, we prove that the energy at any time t also separates completely into adiabatic and nonadiabatic components, after accounting for the secular and normalization terms that appear in the solution of the time-dependent Schrödinger equation via Dirac's method of variation of constants.

A novel sucrose/H+ symport system and an intracellular sucrase in Leishmania donovani.

The flagellated form of pathogenic parasitic protozoa Leishmania, resides in the alimentary tract of its sandfly vector, where sucrose serves as a major nutrient source. In this study we report the presence of a sucrose transport system in Leishmania donovani promastigotes. The kinetics of sucrose uptake in promastigotes are biphasic in nature with both high affinity K(m) (K(m) of ∼ 75 μM) and low affinity K(m) (K(m)∼ 1.

Biochemical properties of the matrix metalloproteinase NtMMP1 from Nicotiana tabacum cv. BY-2 suspension cells.

A zinc-dependent matrix metalloproteinase (NtMMP1) found in the plasma membrane of Nicotiana tabacum cv. Bright Yellow 2 (BY-2) suspension cells is thought to be responsible for the degradation of recombinant proteins secreted into the culture supernatant. We have characterized the proteolytic activity of NtMMP1 by expressing a recombinant derivative lacking the C-terminal transmembrane domain in yeast.

Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway.

Methylglyoxal profoundly stimulates host's immune response against tumor cell by producing reactive oxygen intermediates (ROI's) and reactive nitrogen intermediates (RNI's) [Bhattacharyya, N., Pal, A., Patra, S.

Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance.

NorM, a putative efflux pump of Vibrio cholerae, is a member of the multidrug and toxic compound extrusion family of transporters. We demonstrate that NorM confers resistance to norfloxacin, ciprofloxacin, and ethidium bromide. Inactivation of norM rendered V.

Molecular characterization of the first aromatic nutrient transporter from the sodium neurotransmitter symporter family.

Nutrient amino acid transporters (NATs, subfamily of sodium neurotransmitter symporter family SNF, a.k.a.