Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562.

Glucocorticoids (GCs) are widely used in chemotherapy of hematological malignancies, particularly leukemia. Their effect is mediated by glucocorticoid receptor (GR), a well-known transcription factor. Besides their therapeutic impact, GCs may cause a number of side effects leading to various metabolic complications.

Low-Molecular Collagen Peptides Have Different Effects on Peritoneal Macrophages and Neutrophils.

Two types of phagocytes - neutrophils and macrophages, are very important participants in inflammation. However, the roles played by these cells in the regulation of an inflammation are radically different. Neutrophils initiate and ensure the alteration phase.

CD Antigens: Review of Data Obtained by April' 98.

CD nomenclature may be considered as chronologically set up list of elucidated molecules with each molecule number characterized by the time when it was discovered and thus by the advances in immunology. The Nomenclature Committee of World Health Organization (WHO) and International Union of Immunological Societies (IUIS) have a specialized classification department - Subcommittee on CD Nomenclature. Registration and indexing of the particular CD number to the selected clusters is carried out at International Workshops on Human Differentiation Antigens.

Low Molecular Weight Collagen Peptides Affect Migration, Proliferation and Apoptosis of Mouse Spleen Lymphocytes.

As a consequence of inflammatory tissue degradation collagen proteolysis products may be accumulated in the altered tissue. In this connection, we elaborated a hydrolysis scheme to obtain low molecular weight collagen peptides analogous to those produced in vtiro. To elucidate a possible role of collagen peptides during inflammation their action on lymphocyte migration, proliferation and apoptosis was studied at a wide range of concentrations 1-1000 &mgr;g/ml.

Dynamics and Mechanisms of Interaction of Mouse Spleen Lymphocytes with 3D Collagen Matrix in vitro.

Interaction of immunocompetent cells with extracellular matrix is one of the main stages in their homing and circulation. In this connection we investigated quantitative and dynamic parameters of interaction between splenocytes and 3D collagen matrix in vitro. It was found out that, about 20% of mouse spleen lymphocytes exhibited ability to bind to type I collagen that reflected as their adhesion to and/or migration in collagen matrix.