Primary cutaneous/subcutaneous Ewings sarcoma.

Amongst Ewing sarcoma family of tumours, (EFST), cutaneous/subcutaneous Ewing sarcoma are defined as tumours arising from cutaneous or subcutaneous tissue, not invading the underlying aponeurosis. They are rare tumours, with less than 200 patients published. They are typically small tumours (less than 5cm), and can arise at any anatomical location, with a particular tropism for distal, truncal and head/neck locations, compared to classical Ewing sarcoma.

[Extra-pulmonary metastatic Ewing sarcoma: The French GroupOs diagnostic and therapeutic recommendations].

Patients who develop Ewing sarcoma with extra-pulmonary metastasis have a poor prognosis. A recent French protocol, CombinaiR3, was set up to evaluate the efficacy of induction chemotherapy followed by high-dose chemotherapy and metronomic maintenance treatment. It is now closed for inclusions and while waiting for the results, we propose a French consensus guideline for the management of patients diagnosed with Ewing sarcoma with extra-pulmonary dissemination.

Return to sport and satisfaction after arthroscopic anatomic reconstruction of the lateral ligaments of the ankle in athletes.

Introduction: Ankle sprains, one of the most frequent accidental injuries in traumatology, can lead to chronic instability. Although arthroscopic anatomic ankle ligament reconstruction seems to provide good results, very few studies have specifically examined the outcomes of this procedure. The main goal of this study was to evaluate the rate of and delay to return to sport (RTS) at the preinjury level after anatomic ligament reconstruction and the predictive factors of a RTS in an athletic population.

Influence of Workers' Compensation Status on Functional Recovery and Return to Work After Proximal Hamstring Avulsion Surgery: A Matched Cohort Study.

Background: While patients receiving workers' compensation (WC) often exhibit lower postoperative functional outcomes after orthopaedic surgery, this has not been completely explored with proximal hamstring avulsion injury (PHAI).

Purpose: To (1) investigate the impact of patients with WC status on the functional outcome of PHAI repair and (2) identify risk factors for worse outcomes after PHAI repair.

Study Design: Cohort study; Level of evidence, 3.

Patients' Preferences and Priorities for Mental Health Care Services: A Scoping Review.

Objective: To meet the demand for high-quality care, health care organizations are directing policy and care delivery toward person-centered care. Yet, knowledge of what patients value most in their encounters with the mental health care system is lacking. This scoping review aimed to synthesize the current evidence on patients' preferences during episodes of care within the mental health care system and to identify categories and subthemes of these preferences.

Independent and interactive effects of viral species on risk for lower respiratory tract illnesses in early life.

Importance: All children experience upper respiratory tract illnesses (URI) caused by viral infections. However, some of these illnesses progress to the lower airways. Although studies have found infection with certain viral species are more likely to trigger lower respiratory illnesses (LRIs), a comprehensive analysis of viruses underlying early-life LRIs is lacking.

Points to consider for revising the ICH S7A guideline on safety and secondary pharmacology.

Although the ICH S7A guideline on safety pharmacology largely achieved its objective, a proportion of remaining adverse drug reactions and attrition can be attributed in part to gaps in safety and secondary pharmacology assessments. Advances in science, technology, drug development paradigm and regulatory practices necessitate revisiting and evolving ICH S7A to address these limitations. The anticipated completion of the ICH S7B Q&As by end of 2025 provides an opportunity to integrate its outcomes with ICH S7A into a comprehensive, modality-agnostic sustainable over time framework.

"EpilepSee" Glasses: A Wearable Seizure Prevention Device for Photosensitive Epilepsy.

Temporarily reducing retinal stimulation when exposed to a hazardous photic stimulus by activating a rapidly responding electrochromic material could provide a novel seizure prevention method, referred to as the "EpilepSee Glasses", for people with photosensitive epilepsy.Analysis of an electroencephalogram (EEG) recording has shown reduced photoparoxysmal responses when exposed to flashing light whilst wearing a pair of glasses with one lens covered by an electrochromic material. By characterising the variation of the light seen in a user's field of vision in real time, and exploiting the fact that a stimulus must, on average, be present for at least 1 second to cause a seizure, the glasses' lens only needs to activate upon detection of a potentially harmful stimulus.

Zinc-Containing BEA Zeolites for the Propane Dehydrogenation Reaction: Influence of Adding Yttrium on the Catalytic Properties.

Research results about the structure, acid-base, redox, and adsorption characteristics of zinc(yttrium)-containing dealuminated BEA zeolites (Si/Al=1000), Zn(Y)SiBEA and their catalytic properties in the propane dehydrogenation with CO (CO-PDH) are presented. The catalysts were prepared through a two-step procedure involving complete dealumination of the BEA zeolite followed by the introduction of Zn and Y cations into vacant T-atom sites, by impregnation. The samples obtained were characterized using XRD, XPS, Si DP MAS NMR, low-temperature N ad/desorption, TPR-H, CH/CH (CO, NH)-TPD, and FTIR-Py techniques.

BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia.

Background: Established genetic biomarkers in chronic lymphocytic leukemia (CLL) have been useful in predicting response to chemoimmunotherapy but are less predictive of response to targeted therapies. With several such targeted therapies now approved for CLL, identifying novel, non-genetic predictive biomarkers of response may help to select the optimal therapy for individual patients.

Methods: We coupled data from a functional precision medicine technique called BH3-profiling, which assesses cellular cytochrome c loss levels as indicators for survival dependence on anti-apoptotic proteins, with multi-omics data consisting of targeted and whole-exome sequencing, genome-wide DNA methylation profiles, RNA-sequencing, protein and functional analyses, to identify biomarkers for treatment response in CLL patients.

The ERA Registry Annual Report 2022: Epidemiology of Kidney Replacement Therapy in Europe, with a focus on sex comparisons.

The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper summarizes the ERA Registry Annual Report 2022, with a special focus on comparisons by sex. The supplement of this paper contains the complete ERA Registry Annual Report 2022.

Impact of Systematic Joint Examination (Ultrasound, Functional and Physical) on Treatment Management Decisions in Patients With Haemophilia A in France: Final Data From the Prospective, Observational A-MOVE Study.

Background: Haemophilia management aims to prevent bleeding and preserve joint function. Changes in patients' joint health may influence physicians' decisions to adjust treatment. The Haemophilia Joint Health Score (HJHS) and Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score assess joint health but are not routinely used.

Analysis of temporal survival trends: considerations and best practice.

Monitoring quality of healthcare is vital to ensure that changes made to clinical practice achieve the intended goals. Assessing temporal trends due to the accumulated effect of all changes in clinical practice in a given period is essential in quality monitoring. However, this assesment is compplicated by the fact that numerous of changes might occour over time unrelated to the clinical practice.

The Natural Course of Bosch-Boonstra-Schaaf Optic Atrophy Syndrome.

(Likely) pathogenic variants in NR2F1 are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS, OMIM #615722), a rare neurodevelopmental disorder. Patients present with a variety of symptoms, including intellectual disability, developmental delay, visual impairment, muscular hypotonia, seizures, and/or autistic features. Since it was first described in 2014, the phenotype has steadily expanded.

The short version of the ALR-RSI scale is a valid and reproducible scale to evaluate psychological readiness to return to sport after ankle lateral reconstruction.

Purpose: To develop and validate a short and mini version of the ALR-RSI (Ankle Ligament Reconstruction-Return to Sport after Injury) scale.

Methods: The ALR-RSI scale contains 12 items and was administered to 109 patients following arthroscopic anatomical lateral ankle reconstruction. The short (6-item) and mini (3-item) versions were developed using a systematic selection process to eliminate items based on their category, mean, standard deviation and pertinence.

Association between new-onset atrial fibrillation and adverse clinical outcomes by country of origin: A matched nationwide cohort study.

Background: Incidence and prevalence of atrial fibrillation (AF) is increasing worldwide, and the condition is associated with high risk of adverse clinical outcomes. Increasing global migration results in more diverse patient populations, and knowledge about AF-related outcomes in immigrants is warranted.

Aim: To examine clinical outcomes after AF diagnosis across migrant populations in Denmark.

Modeling energy requirements for oxygen production on the Moon.

Spacecraft using combustion engines require substantial amounts of oxygen for their propellant. The Moon could be a source of oxygen for rocket propellant, since the material composing the lunar surface can be processed to extract oxygen. However, little is known about overall energy requirements of the processes described in the literature for oxygen extraction from lunar regolith.

Effectiveness of protected areas and restricted access in sandy beach biodiversity conservation: A case study from Rio de Janeiro, Southeast Brazil.

Sandy beaches are important socio-ecological systems for human well-being and coastal stability. They are also economic and cultural assets; however, urbanization and human activities threaten their ecosystem services and biodiversity. Thus, it is important to discuss strategies for ecosystem conservation.

Use of deep learning-accelerated T2 TSE for prostate MRI: Comparison with and without hyoscine butylbromide admission.

Objective: To investigate the use of deep learning (DL) T2-weighted turbo spin echo (TSE) imaging sequence with deep learning acceleration (T2DL) in prostate MRI regarding the necessity of hyoscine butylbromide (HBB) administration for high image quality.

Methods: One hundred twenty consecutive patients divided into four groups (30 for each group) were included in this study. All patients received a T2DL (version 2022/23) and a conventional T2 TSE (cT2) sequence on an implemented 3 T scanner and software system.

Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study.

Introduction: Central venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence of -associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.

Methods: We examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.

On the fence: Factors associated with COVID-19 vaccine hesitancy among sexually Minoritized men who use substances in the United States.

Objective: Substance use during the COVID-19 (SARS-CoV-2) pandemic has exponentially increased among sexually minoritized men (SMM), who are more vulnerable to COVID-19 transmission, morbidity, and mortality than their heterosexual counterparts. Understanding the factors that mediate and are associated with COVID-19 vaccine uptake in a national sample of SMM that use substances may inform targeted interventions to maximize public acceptance.

Methods: A cross-sectional analysis was performed using data from a national sample of 2753 SMM in the United States between May 2021-July 2022.

Bridging inequity gaps in healthcare through tailored support: implementation perspectives of the Social Health Bridge-Building Programme.

Background: Equity in access to and outcomes from healthcare is a fundamental pillar of universal healthcare systems. However, these systems have not eliminated social inequities in health. Significant socio-economic disparities persist in access to and utilisation of healthcare services, as well as in the quality and outcomes of care.

Evaluating the feasibility of automating dataset retrieval for biodiversity monitoring.

Aim: Effective management strategies for conserving biodiversity and mitigating the impacts of global change rely on access to comprehensive and up-to-date biodiversity data. However, manual search, retrieval, evaluation, and integration of this information into databases present a significant challenge to keeping pace with the rapid influx of large amounts of data, hindering its utility in contemporary decision-making processes. Automating these tasks through advanced algorithms holds immense potential to revolutionize biodiversity monitoring.

Results of a phase Ib study of olaparib with concomitant radiotherapy in soft-tissue sarcoma: a French sarcoma group study.

Background: Radiotherapy is essential for locoregional control in resectable soft-tissue sarcoma (STS) and remains a key strategy for unresectable STS. PARP inhibitors, such as olaparib, may enhance radiosensitivity by targeting DNA damage repair pathways.

Patients And Methods: This multicenter phase 1b trial evaluated the combination of olaparib and radiotherapy in STS of the limbs or trunk wall.