Publications by authors named "A. Lopes"
Concerns about the SARS-CoV-2 outbreak (COVID-19) continue to persist even years later, with the emergence of new variants and the risk of disease severity. Common clinical symptoms, like cough, fever, and respiratory symptoms, characterize the noncritical patients, classifying them from mild to moderate. In a more severe and complex scenario, the virus infection can affect vital organs, resulting, for instance, in pneumonia and impaired kidney and heart function.
View Article and Find Full Text PDFMethotrexate is an anti-inflammatory and immunomodulatory drug, widely used for moderate to severe psoriasis and other rheumatological conditions such as rheumatoid arthritis, besides some types of malignancies. Side effects are more prevalent in high acute doses but can also be seen in low-dose chronic use, especially in cases of drug-dosing errors. Possible symptoms of toxicity include gastrointestinal, hepatic, hematologic and renal dysfunctions, but may also include mucositis and worsening of the psoriatic lesions.
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- Osteogenesis imperfecta (OI) is a connective tissue disorder known for causing bone fragility but also involves other systemic issues.
- The case report details an elderly patient who experienced acute chest pain and had symptoms like blue sclerae and multiple fractures, prompting an in-depth diagnostic process.
- Despite normal cardiac evaluations, the patient's complex medical history and physical signs highlighted the relevance of examining musculoskeletal factors in diagnosing hereditary conditions like OI.