The relationship between obstructive sleep apnea and Parkinson's disease: a systematic review and meta-analysis.

Background: Obstructive sleep apnea (OSA) is a common sleep disorder in Parkinson's disease (PD). However, the relationship between OSA and PD is still inconsistent. Our study was aimed to evaluate the relationship between PD and OSA.

Coexistent Charcot-Marie-Tooth type 1A and type 2 diabetes mellitus neuropathies in a Chinese family.

Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by duplication of the peripheral myelin protein 22 (PMP22) gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy.

Nerve biopsy findings contribute to diagnosis of multiple mononeuropathy: 78% of findings support clinical diagnosis.

Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and June 2013.

Intraneural perineurioma affecting multiple nerves: a case report and literature review.

Intraneural perineurioma is a neoplasm of perineurial cells, corresponding to WHO grade I. We present a case of intraneural perineurioma affecting multiple nerves, which usually involved one or two of major nerve trunks in one patient. We describe the clinical presentation, magnetic resonance (MR) neurography characteristics, and pathological characteristics.

[Significance of Nogo-A expression of atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis].

Objective: To investigate significance of Nogo-A in atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis (ALS).

Methods: Forty cases which were diagnosed definitely by clinical, pathological or DNA analysis were included. All of the cases underwent muscle biopsies in order to carry out Nogo-A immunostaining.

[The correlation of CAGs repeat size with age of onset in patients with Kennedy's disease].

Objective: To investigate the correlation of CAGs repeat size and age of onset in patients with Kennedy's Disease (KD).

Methods: We detected the number of CAG repeats in the androgen receptor genes in 30 patients with KD. The correlation of CAGs repeat size with age of onset was analyzed.

[The relationship between carotid artery atherosclerosis and hyperhomocysteinaemia].

Objective: To explore the relationship between the carotid artery atherosclerosis (CAA) and the level of homocysteine (Hcy) as well as folate, vitamin B(12) and lipids.

Methods: The diameter of common carotid arteries and internal carotid arteries on both sides were measured by B-mode ultrasound in 126 subjects who were divided into normal and A, B, C, D groups according to the severity of stenosis of CAA. With fasting serum, Hcy as well as folate, vitamin B(12), triglycerides, total cholesterols (TC), low density lipid (LDL), high density lipid (HDL) were detected.

[Establishment of the organotypic model of amyotrophic lateral sclerosis from the SD rats' spinal cord].

Objective: To establish an in vitro model of amyotrophic lateral sclerosis (ALS) from the organotypic culture of SD rats' lumber spinal cord induced by the mitochondrial inhibitor,malonate sodium.

Method: The lumber spinal cord prepared from the 6-day-old SD rats was cut into 350 microm coronarily, cultured on the Millicell-CM inserts which make the spinal cord culturing on the interface between air and fluid. First, the optimum malonate sodium dose was determined by adding different doses into the medium and counting the living motor neuron numbers by using immuno-histochemistry staining.

Immunohistochemical characterisation of pulmonary hyaline membrane in various types of interstitial pneumonia.

Aims: Hyaline membrane (HM) in diffuse alveolar damage (DAD) pattern is frequently detected in the acute stage of interstitial pneumonia (IP). To determine the exact nature of HM, we investigated immunohistochemically 25 cases of HM-containing IP.

Methods: The cases examined using various kinds of antibodies were four cases associated with rheumatoid arthritis, five with usual interstitial pneumonia, two with dermatomyositis, five with viral infection, one case with progressive systemic sclerosis and eight cases caused by other agents.

Typical nemaline bodies presenting in a patient with polymyositis.

A 66-year-old woman presented with a progressive myopathy affecting the proximal limbs and unusual pathological findings of nemaline bodies on muscle biopsy. Histological examination demonstrated that the bodies were mainly located in the subsarcolemmal region of atrophic fibers, exhibited strong immunoreactivity with antibodies to both alpha-actinin and m-actin, and had a typical lattice-like appearance at higher magnification on electron microscopy. These findings were the same as those for nemaline myopathy.