Publications by authors named "A-Z Traore"
Background: Subcutaneous administration of the monoclonal antibody L9LS protected adults against controlled infection in a phase 1 trial. Whether a monoclonal antibody administered subcutaneously can protect children from infection in a region where this organism is endemic is unclear.
Methods: We conducted a phase 2 trial in Mali to assess the safety and efficacy of subcutaneous administration of L9LS in children 6 to 10 years of age over a 6-month malaria season.
Article Synopsis
- CIS43LS is a monoclonal antibody that showed potential to protect against infection in a phase 1 clinical trial, but its effectiveness in endemic regions was unclear.
- A phase 2 trial was conducted in Mali, involving 330 healthy adults, to evaluate the safety and efficacy of CIS43LS through different dosage levels against malaria over a 6-month period.
- Results indicated that participants receiving 40 mg of CIS43LS per kilogram had an 88.2% efficacy rate against infection, while those receiving 10 mg had a 75.0% efficacy rate, showing the antibody's protective ability with relatively minor safety concerns.
Amniotic band syndrome is a rare congenital disorder. The authors report the first cases documented at Souro Sanou University Hospital in Bobo-Dioulasso (CHUSS) in 2 male new borns. The malformations found at birth, were worn only on limbs and were in the form of skin furrow necking with a major lymphedema downstream.
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