Urinary biomarkers of drinking water disinfection byproducts in relation to blood-based liver function parameters among reproductive-aged Chinese women.

Background: Toxicological studies have documented that disinfection byproducts (DBPs), the ubiquitous drinking water pollutants, induce hepatotoxicity. Yet epidemiological evidence is sparse.

Objective: To assess urinary biomarkers of drinking water DBPs in relation to liver function parameters.

Repeated measurements of urinary bisphenol A and its analogues in relation to sperm DNA damage.

Bisphenol A (BPA), a common endocrine disrupting chemical (EDC), has shown detrimental effects on sperm quality and function in experimental models. However, epidemiological evidence is inconsistent and also there exists a notable lack of data on its analogues, such as bisphenol F (BPF) and bisphenol S (BPS). To investigate the relationships between BPA, BPF and BPS exposures and sperm DNA damage, we conducted a cross-sectional study recruiting 474 Chinese men from an infertility clinic in Wuhan, China.

Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study.

Background: Disinfection byproducts (DBPs) have been shown to impair thyroid function in experimental models. However, epidemiological evidence is scarce.

Methods: This study included 1190 women undergoing assisted reproductive technology (ART) treatment from the Tongji Reproductive and Environmental (TREE) cohort from December 2018 to August 2021.

Exposures to drinking water disinfection byproducts and kidney function in Chinese women.

Background: Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse.

Objective: To investigate exposures to DBPs in associations with renal function among women.

Associations of exposure to disinfection by-products with blood coagulation parameters among women: Results from the Tongji reproductive and environmental (TREE) study.

Background: Experimental studies have shown that disinfection byproducts (DBPs) induce coagulotoxicity, but human evidence is scarce.

Objective: This study aimed to explore the relationships of DBP exposures with blood coagulation parameters.

Methods: Among 858 women from the Tongji Reproductive and Environmental (TREE) study, urinary dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) were detected as internal biomarkers of DBP exposures.

Urinary biomarkers of drinking-water disinfection byproducts in relation to diminished ovarian reserve risk: A case-control study from the TREE cohort.

Background: Disinfection byproducts (DBPs) as ovarian toxicants have been documented in toxicological studies. However, no human studies have explored the effects of exposure to DBPs on diminished ovarian reserve (DOR).

Objective: To assess whether urinary biomarkers of exposure to drinking-water DBPs were associated with DOR risk.

Associations between urinary biomarkers of exposure to disinfection byproducts and semen parameters: A repeated measures analysis.

Toxicological studies have demonstrated that disinfection byproducts (DBPs), particularly haloacetic acids, cause testicular toxicity. However, evidence from human studies is sparse and inconclusive. This study included 1230 reproductive-aged men from the Tongji Reproductive and Environmental (TREE) cohort to investigate the associations between repeated measures of DBP exposures and semen parameters.