A systematic review and meta-analysis examining alterations in medial meniscus extrusion and clinical outcomes following high tibial osteotomy.

Background: Medial meniscal extrusion (MME) is both a contributor to and a consequence of medial knee osteoarthritis (OA), with each condition exacerbating the other.High tibial osteotomy (HTO) realigns varus to valgus to alleviate medial compartment stress.This study conducted a systematic review and meta-analysis to evaluate alterations in medial meniscus extrusion values and clinical outcomes following high tibial osteotomy (HTO).

Cellular blueprint of healthy and diseased human epiglottis and subglottis-a study of the Canadian Airways Research (CARE) group.

Background: The larynx consists of the supraglottis, glottis, and subglottis and each differ in tissue composition, lymphatic drainage, ability to counter infections, and response to injuries. However, the cellular mechanisms driving laryngeal homoeostasis remain largely unexplored. As a result, understanding disease pathogenesis within the larynx including idiopathic subglottic stenosis (iSGS) and intubation-related traumatic stenosis has been challenging.

Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology-a study of the Canadian airways research (CARE) group.

Background: First described in 1972, idiopathic subglottic stenosis (iSGS) is a serious chronic orphan disease characterised by recurrent scarring of the subglottis. Although the cause is unknown, iSGS is almost exclusively restricted to Caucasian females typically in their fourth to sixth decade. However, given its rare incidence (1:400,000), understanding the clinical trajectory and molecular factors associated with iSGS disease development and prognosis has been difficult.

A pathogenic NR2F1 gene variant disrupts transcriptional activity and causes severe neurodevelopmental delay in Bosch-Boonstra-Schaaf syndrome.

Introduction: Nuclear receptor subfamily 2, group F, member 1 (NR2F1) gene variations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome. The NR2F1 genotype correlates with its phenotype; variants within the DNA-binding domain may cause severe psychomotor developmental disorders. However, the mechanisms underlying these phenotypes remain unclear.

Nanocellulose-Derived Hierarchical Carbon Framework-Supported P-Doped MoO Nanoparticles for Optimizing Redox Kinetics in Lithium-Sulfur Batteries.

The integration of nanocatalysts into the separators of lithium-sulfur batteries (LSBs) boosts the polysulfide conversion efficiency. However, the aggregation of catalyst nanoparticles diminishes the active surface area. Moreover, densely packed catalyst-modified layers often hinder ion transport rates and impede access to the catalytic sites.

Three-dimensional comparative analysis of upper central incisors external apical root resorption/ incisive canal changes in first premolar extraction cases: clear aligners Versus passive self-ligating fixed braces.

Objective: To assess the upper central incisor's (U1) external apical root resorption (EARR) and incisive canal (IC) changes and their influencing factors under clear aligners and passive self-ligating fixed braces in first premolar extraction cases using CBCT.

Materials And Methods: This retrospective study included 60 participants (120 teeth) with similar baseline characteristics based on the American Board of Orthodontics discrepancy index scores. Participants were divided into clear aligner (CA) and passive self-ligating fixed appliance (FA) groups, with 30 participants per group.

Effectiveness of Dyadic Interventions on Quality of Life for Cancer Patients and Family Caregivers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Background: Increases in cancer survivorship negatively impact patients and family caregivers, decreasing quality of life. Previous dyadic interventions involved them as a unit and focused on their outcomes, but inconsistent results existed in influencing quality of life.

Objectives: To assess dyadic intervention effect on quality of life for cancer patients and family caregivers across different cancer types and intervention durations.

Inflammation-targeting nanoparticles impede neutrophil infiltration and scavenge ROS for acute lung injury alleviation.

Acute lung injury (ALI) is a severe acute diffuse lung disease caused by noncardiac factors, primarily associated with uncontrolled inflammation and excessive reactive oxygen species (ROS). In severe cases, ALI develops into acute respiratory distress syndrome (ARDS) with high mortality. The current clinical treatments of ALI have shown limited efficacy and fail to reduce mortality.

Expanding the phenotypic spectrum of DNM1-related disorders: novel GTPase domain variants and their diverse neurological outcomes.

Background: Pathogenic DNM1 variants cause early-onset developmental and epileptic encephalopathy (DEE). The GTPase domain of the DNM1 protein has the most commonly affected sites.

Aim: This study aimed to delineate additional patients with DNM1-related disorders harboring novel GTPase domain variants.

Myocardial MRI Cine Radiomics: A Novel Approach to Risk-Stratification for Major Adverse Cardiovascular Events in Patients With ST-Elevation Myocardial Infarction.

Background: The incremental prognostic value of integrating myocardial cine radiomics into predictive models for major adverse cardiovascular events (MACE) risk in patients with ST-elevation myocardial infarction (STEMI) is unclear.

Purpose: To determine if myocardial cine radiomics can improve risk assessment for MACE when combined with clinical information and cardiac MRI parameters in STEMI patients.

Study Type: Retrospective.

Lattice atom-bridged chemical bond interface facilitates charge transfer for boosted photoelectric response.

The construction of chemical bonds at heterojunction interfaces currently presents a promising avenue for enhancing photogenerated carrier interfacial transfer. However, the deliberate modulation of these interfacial chemical bonds remains a significant challenge. In this study, we successfully established a junction composed of atomic-level Pt-doped CeO and 2D metalloporphyrins metal-organic framework nanosheets (Pt-CeO/CuTCPP(Fe)), which enables the realization of photoelectric enhancement by regulating the interfacial Fe-O bond and optimizing the built-in electric field.

Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma.

Background: Epidermal differentiation disorders (EDDs, a.k.a.

Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway.

Background: Split-hand/foot malformation (SHFM) is a congenital disability characterized by the absence or hypoplasia of the central ray of the hands and/or feet. This study reports a causative variant in the TP63 gene in a Chinese family exhibiting limb anomalies associated with SHFM4.

Methods: Enrolled in this study was a Chinese family with limb anomalies without any other clinical features.

MXene Hollow Microsphere-Boosted Nanocomposite Electrodes for Thermocells with Enhanced Thermal Energy Harvesting Capability.

Thermal energy, constantly being produced in natural and industrial processes, constitutes a significant portion of energy lost through various inefficiencies. Employing the thermogalvanic effect, thermocells (TECs) can directly convert thermal energy into electricity, representing a promising energy-conversion technology for efficient, low-grade heat harvesting. However, the use of high-cost platinum electrodes in TECs has severely limited their widespread adoption, highlighting the need for more cost-effective alternatives that maintain comparable thermoelectrochemical performance.

Lattice Strain-Modulated Trifunctional CoMoO Polymorph-Based Electrodes for Asymmetric Supercapacitors and Self-Powered Water Splitting.

Developing efficient, multifunctional electrodes for energy storage and conversion devices is crucial. Herein, lattice strains are reported in the β-phase polymorph of CoMoO within CoMoO@CoO heterostructure via phosphorus doping (P-CoMoO@CoO) and used as a high-performance trifunctional electrode for supercapacitors (SCs), hydrogen evolution reaction (HER), and oxygen evolution reaction (OER) in alkaline electrolytes. A tensile strain of +2.

Radiosynthesis and evaluation of novel F labeled PET ligands for imaging monoacylglycerol lipase.

Monoacylglycerol lipase (MAGL) is a 33 kDa cytosolic serine hydrolase that is widely distributed in the central nervous system and peripheral tissues. MAGL hydrolyzes monoacylglycerols into fatty acids and glycerol, playing a crucial role in endocannabinoid degradation. Inhibition of MAGL in the brain elevates levels of 2-arachidonoylglycerol and leads to decreased pro-inflammatory prostaglandin and thromboxane production.

[Analysis of FBN1 gene mutations in six Chinese pedigrees affected with Marfan syndrome].

Objective: To determine the types of genetic variants in six Chinese pedigrees affected with Marfan syndrome (MFS) and analyze their clinical characteristics and molecular pathogenesis.

Methods: Six MFS pedigrees presented at the Taizhou Enze Medical Center (Group) between 2017 and 2022 were selected as the study subjects. Clinical data of pedigrees were retrospectively analyzed.

Deep Learning-Based Super-Resolution Reconstruction on Undersampled Brain Diffusion-Weighted MRI for Infarction Stroke: A Comparison to Conventional Iterative Reconstruction.

Background And Purpose: DWI is crucial for detecting infarction stroke. However, its spatial resolution is often limited, hindering accurate lesion visualization. Our aim was to evaluate the image quality and diagnostic confidence of deep learning (DL)-based super-resolution reconstruction for brain DWI of infarction stroke.

Functional study of three cases with novel TBX19 variants.

Purpose: Congenital isolated adrenocorticotropic hormone deficiency (CIAD) is an autosomal recessive disorder. This study identifies novel TBX19 variants for CIAD patients, explores its possible effect mechanism at the structural, functional and protein levels, and guides clinicians better understand the condition.

Methods: The clinical characteristics of three CIAD children were summarized.

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.

During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro-crossover RING-domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mouse and determine their interdependencies.

Mutation in and a Variant Linked to a Severe Sporadic Infant Dilated Cardiomyopathy Case.

Structural or electrophysiologic cardiac anomalies may compromise cardiac function, leading to sudden cardiac death (SCD). Genetic screening of families with severe cardiomyopathies underlines the role of genetic variations in cardiac-specific genes. The present study details the clinical and genetic characterization of a malignant dilated cardiomyopathy (DCM) case in a 1-year-old Mexican child who presented a severe left ventricular dilation and dysfunction that led to SCD.

Uncertain significance and molecular insights of CPLANE1 variants in prenatal diagnosis of Joubert syndrome: a case report.

Background: Prenatal whole exome sequencing (WES) is becoming an increasingly used diagnostic tool for fetuses with structural anomalies. However, the identification of variants of uncertain significance (VUS) in clinically relevant genes can significantly complicate prenatal diagnosis and genetic counseling.

Case Presentation: A fetus conceived through in vitro fertilization at the third attempt presented with polydactyly and molar tooth sign at 24 + 6 weeks of gestation.

Case Report: A potentially pathogenic new variant of the gene found in a family experiencing autosomal dominant tubulointerstitial kidney disease.

Background: Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by -causing pathogenic variants (ADTKD-) is a rare group of heritable diseases. ADTKD- often manifests in childhood with symptoms such as mild hypotension, chronic kidney disease, hyperkalemia, anemia, and acidosis. The diagnosis of ADTKD- remains challenging.

Establishment and application of a high-performance liquid chromatography-mass spectrometry method for analysis of 15 bisphenols and halogenated phenols in tea.

Using high-performance liquid chromatography-mass spectrometry, fifteen bisphenols and halogenated phenols were simultaneously analyzed in tea for the first time in China. Response surface methodology was used to optimize sample preparation conditions based on QuEChERS. Finally, the limits of detection and the limits of quantification were 0.

Early diagnosis of type 2 diabetes mellitus in patients with psoriasis: Construction of a multifactorial diagnostic model.

Background: Type 2 diabetes mellitus (T2DM) is a significant comorbidity of psoriasis that exerts a long-term detrimental effect on patients. Early T2DM detection in psoriasis patients is essential for timely medical intervention and the prevention of further complications.

Objective: To develop a diagnostic model and introduce a web-based calculator for assessing the risk of T2DM in patients with psoriasis.