Dynamic pattern of postprandial bile acids in paediatric non-alcoholic fatty liver disease.

Background: Dysregulation of bile acids (BAs), as important signalling molecules in regulating lipid and glucose metabolism, contributes to the development of non-alcoholic fatty liver disease (NAFLD). However, static BA profiles during fasting may obscure certain pathogenetic aspects. In this study, we investigate the dynamic alterations of BAs in response to an oral glucose tolerance test (OGTT) among children with NAFLD.

Secondary bile acids improve risk prediction for non-invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease.

Background: Dysregulated bile acid (BA) metabolism has been linked to steatosis, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).

Aim: To determine whether circulating BA levels accurately stage liver fibrosis in NAFLD.

Methods: We recruited 550 Chinese adults with biopsy-proven NAFLD and varying levels of fibrosis.

Allometric scaling of biomass with nitrogen and phosphorus above- and below-ground in herbaceous plants varies along water-salinity gradients.

Biomass allocation affects the ability of plants to acquire resources and nutrients; a limited allocation of nutrients, such as nitrogen and phosphorus, affects ecological processes. However, little research has been conducted on how plant allocation patterns change and on the trade-offs involved in allocation strategies when microhabitat gradients exist. We selected a 3.