Publications by authors named "A-L Hachulla"
Background: Patients with inflammatory rheumatic and musculoskeletal diseases (iRMD) receiving mycophenolic acid (MPA) may have a less favourable outcome from COVID-19 infection. Our aim was to investigate whether MPA treatment is associated with severe infection and/or death.
Methods: IRMD patients with and without MPA treatment with highly suspected/confirmed COVID-19 were included in this observational multicentre study.
Magnetic resonance imaging (MRI) can be used to measure cardiac output (CO) non-invasively, which is a paramount parameter in pulmonary hypertension (PH) patients. We retrospectively compared stroke volume (SV) obtained with MRI (SV) in six localisations against SV measured with thermodilution (TD) (SV) and against each other in 24 patients evaluated in our PH centre using Bland and Altman (BA) agreement analyses, linear correlation, and intraclass correlation (ICC). None of the six tested localisations for SV reached the predetermined criteria for interchangeability with SV, with two standard deviations (2SD) of bias between 24.
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- Systemic sclerosis is a severe autoimmune disease, and mesenchymal stromal cells (MSCs) show potential for treatment due to their immunomodulatory and antifibrotic properties, although their safety in patients has not been confirmed.
- A phase 1/2 study at Saint-Louis Hospital in Paris aimed to determine the safety and feasibility of injecting allogeneic MSCs from family donors into patients with severe diffuse systemic sclerosis.
- The study involved 20 eligible patients, assessing immediate infusion tolerance and monitoring serious adverse events over a 24-month follow-up period.
Pulmonary hypertension and interstitial lung disease are the two main causes of death in systemic sclerosis. The hallmark of these complications is dyspnea on exertion. Assessment of dyspnea in systemic sclerosis is based on a questionnaire; 6-minute walk test and Borg index.
View Article and Find Full Text PDFWe evaluated the value of serum amyloid P component scintigraphy (123I-SAP) and labial salivary gland biopsy in four patients with apparently localized amyloidosis. One patient had pharyngeal amyloidosis, the second laryngeal amyloidosis, the third retro-ocular amyloidosis and the fourth had carpal tunnel syndrome. Three patients (no 2, no 3, no 4) have abnormal whole body retention of 123I-SAP and positive labial salivary gland biopsy for amyloidosis.
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