Publications by authors named "A-K Nyman"
Background And Purpose: CNS embryonal tumor with amplification (ET, PLAGL) is a newly identified, highly malignant pediatric tumor. Systematic MRI descriptions of ET, PLAGL are currently lacking.
Materials And Methods: MRI data from 19 treatment-naïve patients with confirmed ET, PLAGL were analyzed.
Article Synopsis
- KRAS is a small GTPase that acts as a switch for cell signaling, and mutations in KRAS are linked to various cancers, notably pancreatic, lung, and colorectal cancers.
- Recent efforts to target specific KRAS mutations, particularly G12C and G12D, have shown some success, but other mutations like G12V and G13D remain difficult to treat.
- The study presents a new KRAS G13D conformer structure that could be targeted by a developed monoclonal antibody, which effectively inhibited KRAS signaling in cancer cells, suggesting a new avenue for therapeutic development against this mutation.
Complications of diabetes is a major health problem affecting multiple organs including bone, where the chronic disease increases the risk of fragility fractures. One hypothesis suggests a pathogenic role for hyperglycemia-induced modification of proteins, a.k.
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- Direct air capture (DAC) of CO2 is essential to mitigate global climate change, and research is focused on various materials, particularly alkaline inorganic metal oxides that create carbonates.
- This study investigates early d-transition metal peroxides, specifically tetraperoxovanadates, exploring their conversion pathways to produce CO-capturing compounds through various experimental techniques, including X-ray crystallography and spectrometry.
- The reactions are influenced by the type of alkali metal used, affecting both the stability and efficiency of CO capture, revealing that while heavier alkalis enhance capture speed, they don't necessarily improve the total amount of CO captured.
The cardiac sodium-calcium exchanger (NCX1) is important for normal Na- and Ca-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disruption of the potentially inhibitory pSer68-PLM-NCX1 interaction might be a therapeutic strategy to increase NCX1 activity in cardiac disease.
View Article and Find Full Text PDFA wide range of solid phases for SPE (solid-phase extraction) (n=14) and HPLC (n=9) were compared regarding the chromatographic retention of acrylamide. For SPE, a hydroxylated polystyrene-divinylbenzene copolymer phase (ENV+) gave the strongest retention. Twenty millilitre of water per gram solid phase could be passed with less than 5% loss of acrylamide from the column, thus enabling significant enrichment of food extracts.
View Article and Find Full Text PDFKinetic properties of the monomeric enzyme dUTPase from herpes simplex virus type 1 (HSV) were investigated and compared to those previously determined for homotrimeric dUTPases of bacterial and retroviral origins. The HSV and Escherichia coli dUTPases are equally potent as catalysts towards the native substrate dUTP with a kcat/K(M) of about 10(7) M(-1) s(-1) and a K(M) of 0.3 microM.
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