Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants.

Background: Current literature informs us that bivalent vaccines will generate a broader serum neutralizing antibody response to multiple SARS-CoV-2 variants, but studies on how this breadth relates to the memory B cell (MBC) and T cell responses are sparse. This study compared breadth of neutralising antibody, and memory B and T cell responses to monovalent or a bivalent ancestral/Omicron BA.1 COVID-19 booster vaccine.

The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing.

Two-pore domain K (K) channels generate K leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K channels exhibit distinct expression and function across neuronal tissues. TWIK-related spinal cord K channel (TRESK) is a K channel with a particularly enriched role in sensory neurons and pain pathways.

Metformin and Myocardial Injury in Patients With Diabetes and ST-Segment Elevation Myocardial Infarction: A Propensity Score Matched Analysis.

Background: Although animal studies have documented metformin's cardioprotective effects, the impact in humans remains elusive. The study objective was to explore the association between metformin and myocardial infarct size in patients with diabetes presenting with ST-segment elevation myocardial infarction.

Methods And Results: Data extraction used the National Cardiovascular Data CathPCI Registry in all patients with diabetes aged >18 years presenting with ST-segment elevation myocardial infarction at 2 academic medical centers from January 2010 to December 2013.

Membrane potential generation and calcium transport in plasma membrane enriched fractions from fetal human brain.

Plasma membrane fractions isolated from fetal human brain of 14-19 weeks of gestation are capable of generating a membrane potential of 30-50 mV as a response to a gradient of K+ ions. Valinomycin, a K+ conducting ionophore, does not affect the membrane potential whereas it is markedly reduced by veratridine which opens Na+ channels in excitable membranes. The membrane fractions concentrate Ca2+ by an ATP-dependent mechanism.