Publications by authors named "A-Jin Lee"

Background: The clinical utility of urinary red blood cell (RBC) distribution (URD) remains limited. This study aimed to compare the diagnostic performance of URD and dysmorphic RBC (dRBC) in a multicenter study.

Methods: This study enrolled 703 patients who visited four tertiary medical centers in Korea.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on identifying risk factors for cancer recurrence in patients with early-stage endometrioid endometrial cancer who achieved complete response through fertility-sparing hormonal treatment.
  • A retrospective analysis of 178 patients revealed that 79.8% achieved complete response, but 59.9% experienced recurrence during a median follow-up of 44 months.
  • Key factors associated with higher recurrence risk included being older than 35 years and not becoming pregnant after achieving complete response, suggesting that these patients require close monitoring for potential recurrence.
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to determine if intraoperative rupture during surgeries for early-stage epithelial ovarian cancer affects patient outcomes, specifically focusing on progression-free survival (PFS).
  • - Researchers analyzed data from 338 patients (197 unruptured and 141 ruptured) and found no significant difference in 5-year PFS before matching but a concerning trend after adjusting for other factors, particularly in patients with aggressive tumor types.
  • - The conclusions suggest that while the effect of rupture on PFS wasn’t statistically significant, it could still have negative implications for treatment and outcomes, emphasizing the importance of preventing rupture during surgery.
View Article and Find Full Text PDF
Article Synopsis
  • The report examines the outcomes of advanced ovarian cancer patients who underwent bowel surgery as part of maximal cytoreductive surgery, comparing results between surgeries performed by gynecologic oncologists (GOs) and general surgeons (GSs).
  • It involved 761 patients, revealing that both groups had similar characteristics and complication rates, but GOs had shorter operation times.
  • The study concludes that GOs can safely and feasibly perform bowel surgeries without impacting patient survival, suggesting a need for enhanced training for GOs in this area.
View Article and Find Full Text PDF

Mutations in the gene are associated with autosomal recessive spastic ataxia of Charlevoix-Saguenay disease (ARSACS) or complex clinical phenotypes of Charcot-Marie-Tooth disease (CMT). This study aimed to identify mutations in a Korean CMT cohort with cerebellar ataxia and spasticity by whole exome sequencing (WES). As a result, eight pathogenic mutations in four families were identified as the underlying causes of these complex phenotypes.

View Article and Find Full Text PDF

Autosomal recessive Nonaka distal myopathy is a rare autosomal recessive genetic disease characterized by progressive degeneration of the distal muscles, causing muscle weakness and decreased grip strength. It is primarily associated with mutations in the gene, which encodes a key enzyme of sialic acid biosynthesis (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). This study was performed to find mutations in six independent distal myopathy patients with or without peripheral neuropathy using whole-exome sequencing (WES).

View Article and Find Full Text PDF

: The purpose of this study was to analyze the protein overexpression and gene amplification of HER2 in endometrial carcinoma (EC) and to evaluate its role as a prognostic factor in Korean women. : A tissue microarray (TMA) was constructed from samples from 191 patients with diverse histologic types of EC. HER2 protein expression and gene amplification status were analyzed using immunohistochemistry (IHC) and silver in situ hybridization (SISH), respectively.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigated the effectiveness of lymphadenectomy (removal of lymph nodes) in patients with early-stage epithelial ovarian cancer (EOC) to see if it improves survival rates compared to those who did not undergo the procedure.
  • The research included 586 patients and found no significant difference in survival rates between the lymphadenectomy group and the non-lymphadenectomy group, although those with serous histology did experience better disease-free survival with lymphadenectomy.
  • Despite some potential benefits, the lymphadenectomy group had longer surgery times and higher rates of complications, suggesting it should be considered carefully based on individual patient factors.
View Article and Find Full Text PDF

Rab40 proteins are an atypical subgroup of Rab GTPases containing a unique suppressor of the cytokine signaling (SOCS) domain that is recruited to assemble the CRL5 E3 ligase complex for proteolytic regulation in various biological processes. A nonsense mutation deleting the C-terminal SOCS box in the gene was identified in a family with axonal peripheral neuropathy (Charcot-Marie-Tooth disease type 2), and pathogenicity of the mutation was assessed in model organisms of zebrafish and . Compared to control fish, zebrafish larvae transformed by the human mutant showed a defective swimming pattern of stalling with restricted localization and slower motility.

View Article and Find Full Text PDF

Objective: To identify the risk factors for failure of first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy in patients with advanced ovarian cancer.

Method: Patients with stage III-IV epithelial ovarian cancer who received first-line PARPi maintenance therapy were retrospectively reviewed. Clinicopathologic factors were compared between two groups-recur/progression of disease (PD) and non-recur/PD.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate the surgical outcomes of laparoscopically assisted vaginal hysterectomy (LAVH) in patients with benign conditions and examine the impact of resident involvement on these outcomes.
  • A total of 683 patients were reviewed, with findings showing no significant difference in 30-day postoperative morbidity between surgeries with resident involvement (3.8%) and those without (2.5%).
  • The research concluded that resident participation in LAVH doesn't negatively affect patient safety, suggesting it can be an effective method for training while maintaining care standards.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to find factors linked to disease recurrence in patients with early-stage cervical cancer (2018 FIGO stage IA to IB1) who were treated using minimally invasive surgery (MIS) between 2010 and 2021.
  • Out of 722 patients, 49 (6.8%) had disease recurrence, with notable five-year disease-free survival (90.7%) and overall survival (98.1%) rates; factors associated with higher recurrence risk included residual disease, specific surgical techniques, and positive resection margins.
  • Findings suggest that patients with cervical tumors ≤2 cm might be at risk for peritoneal recurrences and that those diagnosed through conization typically exhibit low-risk
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess adverse pregnancy outcomes in women who previously had endometrial cancer (EC) by analyzing data from the Korean National Health Insurance database.
  • Results showed that women with a history of EC had higher risks for multiple births, caesarean sections, and preterm births compared to those without, after adjusting for factors like age and health conditions.
  • However, there were no significant differences in other complications like pre-eclampsia or gestational diabetes, indicating limited evidence of increased risks overall, which can help inform treatment decisions for patients with EC.
View Article and Find Full Text PDF

Objectives: To evaluate oncologic and pregnancy outcomes of fertility-sparing treatment (FST) using progestin in patients with stage I grade 2 endometrioid endometrial cancer (EC) without myometrial invasion (MI) or grade 1-2 with superficial MI.

Methods: Multicenter data of patients with stage I grade 2 EC without MI or grade 1-2 EC with superficial MI, who received FST between 2005 and 2021, were analyzed. Cox regression analysis identified independent factors for progressive disease (PD) during the FST.

View Article and Find Full Text PDF

In the Laparoscopic Approach to Cervical Cancer trial, minimally invasive surgery (MIS) has been associated with significantly lower disease-free survival and overall survival rates. The proposed reasons for the increased recurrence and mortality associated with MIS are uterine manipulation, the effect of insufflation gas (CO), and intracorporeal colpotomy. We applied 2 techniques during surgery to reduce tumor spillage in laparoscopic radical hysterectomy (LRH), which included avoiding using a uterine manipulator and containing the colpotomy using an endoscopic stapler.

View Article and Find Full Text PDF

Background: Urinary crystals are the most diverse forms of urine sediments. Reference images for typical urinary crystals are common, however, but images for interpreting atypical urinary crystals are very rare. The authors reviewed various forms and solubility tests of urine crystals to interpret atypical crystals found in clinical specimens.

View Article and Find Full Text PDF

Duplication and deletion of the peripheral myelin protein 22 (PMP22) gene cause Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP), respectively, while point mutations or small insertions and deletions (indels) usually cause CMT type 1E (CMT1E) or HNPP. This study was performed to identify PMP22 mutations and to analyze the genotype−phenotype correlation in Korean CMT families. By the application of whole-exome sequencing (WES) and targeted gene panel sequencing (TS), we identified 14 pathogenic or likely pathogenic PMP22 mutations in 21 families out of 850 CMT families who were negative for 17p12 (PMP22) duplication.

View Article and Find Full Text PDF

Objective: To assess the outcomes of retreatment using progestin for recurrence after a complete response with fertility-sparing treatment in patients with early endometrial cancer.

Methods: We retrospectively reviewed the data of patients with presumed stage IA, grade 1 endometrioid endometrial cancer who developed intra-uterine recurrence after a complete response with fertility-sparing treatment using progestin. Oncological and pregnancy outcomes were analyzed after repeated fertility-sparing treatment.

View Article and Find Full Text PDF

Objective: To compare the effects of minimally invasive surgery (MIS) and open surgery (OPS) on the risk of recurrence and mortality in patients with endometrial cancer (EC) of high-risk histology (grade 3 endometrioid adenocarcinoma, papillary serous carcinoma [PS], clear cell carcinoma [CC], and carcinosarcoma) using meta-analysis.

Material And Methods: We systematically reviewed published studies comparing MIS and OPS in EC patients with high-risk histology until January 2022. The endpoints were recurrence and mortality rate.

View Article and Find Full Text PDF

This study aimed to determine whether endocervical glandular involvement (GI) affects the clinical prognosis of patients with cervical intraepithelial neoplasia (CIN) III who underwent the loop electrosurgical excision procedure (LEEP). This retrospective study included 250 patients who underwent LEEP for the treatment of CIN III between August 2005 and May 2020. The medical records of 234 patients were analyzed; 137 (58.

View Article and Find Full Text PDF

Background: Charcot-Marie-Tooth disease type 1C (CMT1C) is a rare subtype associated with LITAF gene mutations. Until now, only a few studies have reported the clinical features of CMT1C.

Objective: This study was performed to find CMT1C patients with mutation of LITAF in a Korean CMT cohort and to characterize their clinical features.

View Article and Find Full Text PDF

Small heat shock proteins (sHSPs) are ATP-independent chaperones that help correct the folding of denatured proteins and protect cells from stress. Mutations in , , and are implicated in inherited peripheral neuropathies (IPNs), such as Charcot-Marie-Tooth disease type 2 (CMT2) and distal hereditary motor neuropathies (dHMN). This study, using whole exome sequencing or targeted gene sequencing, identified 9 pathogenic or likely pathogenic variants in these three sHSP genes from 11 Korean IPN families.

View Article and Find Full Text PDF

This study compared survival outcomes for patients with stage IB1 to IIA2 (International Federation of Gynecology and Obstetrics stage 2009) cervical cancer who underwent open radical hysterectomy (ORH) versus those who underwent minimally invasive radical hysterectomy (MIRH) using vaginal colpotomy (VC).Data for 550 patients who were diagnosed with cervical cancer at our institution during the period August 2005 to September 2018 was retrospectively reviewed. Of these, 116 patients who underwent radical hysterectomy (RH) were selected after applying the exclusion criteria.

View Article and Find Full Text PDF

Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy. Mutations in the neurofilament light polypeptide (NEFL) gene produce diverse clinical phenotypes, including demyelinating (CMT1F), axonal (CMT2E), and intermediate (CMTDIG) neuropathies. From 2005 to 2020, 1,143 Korean CMT families underwent gene sequencing, and we investigated the clinical, genetic, and neuroimaging spectra of NEFL-related CMT patients.

View Article and Find Full Text PDF

Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer.

Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session5ad6olb1b1jkt8lofibe8tqlp6bou4l1): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once