Unexpected metabolic rewiring of CO fixation in H-mediated materials-biology hybrids.

A hybrid approach combining water-splitting electrochemistry and H-oxidizing, CO-fixing microorganisms offers a viable solution for producing value-added chemicals from sunlight, water, and air. The classic wisdom without thorough examination to date assumes that the electrochemistry in such a H-mediated process is innocent of altering microbial behavior. Here, we report unexpected metabolic rewiring induced by water-splitting electrochemistry in H-oxidizing acetogenic bacterium that challenges such a classic view.

TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.

The molecular mechanisms underlying premature ovarian failure, which seriously impacts the physical and psychological health of patients, are not fully understood. Here, we present the role of TRDMT1 in reactive oxygen species-induced granulosa cells death, which is considered an important cause of premature ovarian failure. We found that reactive oxygen species were increased in a HO dose-dependent manner and accompanied by the nuclear shuttling of TRDMT1, increased DNA damage and increased apoptosis of granulosa cells.

Positron-emission tomography-based staging reduces the prognostic impact of early disease progression in patients with follicular lymphoma.

Background: Previous studies reported that early progression of disease (POD) after initial therapy predicted poor overall survival (OS) in patients with follicular lymphoma (FL). Here, we investigated whether pre-treatment imaging modality had an impact on prognostic significance of POD.

Methods: In this retrospective study, we identified 1088 patients with grade I-IIIA FL; of whom, 238 patients with stage II-IV disease were initially treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP), and 346 patients were treated with rituximab-based chemotherapy.

T6SS and ExoA of flesh-eating in peritonitis and necrotizing fasciitis during mono- and polymicrobial infections.

An earlier report described a human case of necrotizing fasciitis (NF) caused by mixed infection with 4 strains (NF1-NF4). While the NF2, NF3, and NF4 strains were clonal and possessed exotoxin A (ExoA), the NF1 strain was determined to be phylogenetically distinct, harboring a unique type 6 secretion system (T6SS) effector (TseC). During NF1 and NF2 mixed infection, only NF1 disseminated, while NF2 was rapidly killed by a contact-dependent mechanism and macrophage phagocytosis, as was demonstrated by using in vitro models.

Inhalation bioaccessibility of polycyclic aromatic hydrocarbons in heavy PM pollution days: Implications for public health risk assessment in northern China.

Airborne (PM) with aerodynamic diameter ≤ 2.5 μm was collected from 4 types of cities in northeast China during the heating period. The objectives of this study were to assess the concentrations variation of PM-bound 12 carcinogenic polycyclic aromatic hydrocarbons (PAH), to study the influence of simulated lung fluids on bioaccessibility of PAH and to estimate the variation of lifetime excess cancer risk to the residents, artificial lysosomal fluid (ALF) and Gamble's solution were used.