Publications by authors named "A-C Lesage"
Article Synopsis
- The study investigates the relationship between body mass index (BMI) and Parkinson's disease (PD) using a method called Mendelian randomization to determine if higher genetically predicted BMI is linked to a lower incidence of PD.
- Researchers analyzed genetic data from large groups of individuals, including over 800,000 for BMI and nearly 29,000 for PD, focusing on factors like age, disease duration, and gender to examine the associations.
- Results indicated an inverse relationship between genetically predicted BMI and PD, particularly among younger participants and women, suggesting that lower BMI may be associated with a higher risk of developing Parkinson's disease.
Article Synopsis
- Some patients with metastatic melanoma (a type of skin cancer) don't get better from usual treatments. Scientists are looking at personalized medicine, which means tailoring treatment to the patient’s specific cancer.
- In a study, 26 patients who found specific genetic changes in their cancer received personalized treatments, with some seeing good results.
- The study showed that using advanced testing followed by targeted therapy might help patients whose melanoma didn't respond to regular treatments.
Article Synopsis
- - This study investigates the genetic factors influencing the age at onset (AAO) of Parkinson's disease (PD), aiming to address the inconsistencies in previous research and validate findings through a meta-analysis of diverse populations.
- - The meta-analysis combined data from the COURAGE-PD Consortium, which included over 8,500 patients primarily of European origin, and the International Parkinson Disease Genomics Consortium, reaching a total of nearly 26,000 participants.
- - The research confirmed a known genetic variant associated with PD AAO and discovered two genome-wide significant signals on chromosome 4, contributing new insights into the genetic basis of the disease's onset.
Objectives: This study aimed to assess the incidence of amikacin plasma peak concentration (C) below 60 mg·L in critically ill children receiving an amikacin dosing regimen of 30 mg kg·day. Secondary objectives were to identify factors associated with low C and to assess the incidence of acute kidney injury (AKI).
Methods: A retrospective observational study was performed in two French pediatric intensive care units.
Complicated structures where oxygen and fluorine are found together in one framework, where deviations from Pauling's second crystal rule (PSCR) are expected, often result in structures with important physical properties. The [NbOF5]2- anion and therefore all the individual Nb-O and Nb-F bonds are ordered in noncentrosymmetric KNaNbOF5 and centrosymmetric CsNaNbOF5. The Na/K- and Na/Cs-O/F interactions in these phases, in particular the expected deviations from PSCR and the bond valence model, reveal the essential role of the small potassium cations in the acentric packing of the [NbOF5]2- anion.
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- The reaction of specific tantalum complexes with dehydroxylated silica leads to the formation of monosiloxy surface complexes by releasing alkane ligands.
- EXAFS data suggests that an adjacent siloxane bridge acts as an additional stabilizing ligand for these complexes, enhancing their structural integrity.
- In propane metathesis, the catalyst that incorporates a highly electrophilic active site is essential, as indicated by the inactivity of another surface complex that lacks this feature.
The Saccharomyces cerevisiae prohormone-processing enzyme Kex2p is biosynthesized as an inactive precursor extended by its N-terminal proregion. Here we show that deletion of the proregion renders Kex2p inactive both in vivo and in vitro. Absence of the proregion impaired glycosylation and stability and resulted in the retention of the enzyme in the endoplasmic reticulum.
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