A Phase I Trial of the Dual MET Kinase/OCT-2 Inhibitor OMO-1 in Metastatic Solid Malignancies Including MET Exon 14 Mutated Lung Cancer.

Introduction: Targeted therapy in non-small cell lung cancer (NSCLC) patients with mesenchymal epithelial transition (MET) exon 14 skipping mutations (METex14) and MET amplifications has improved patients' outcomes. The development of more potent MET kinase inhibitors could further benefit these patients. The aim of this trial is to determine the safety and recommended phase 2 dose (RP2D) of OMO-1 (an oral dual MET kinase/OCT-2 inhibitor) and to assess preliminary clinical efficacy in METex14-positive NSCLC and other MET-positive solid tumors.

Progress Against Cancer in Kuwait: Trends in Incidence, Survival and Mortality.

Introduction: To assess progress against cancer, trends in incidence, survival and mortality need to be interpreted simultaneously.

Methods: Data were obtained from the Kuwait Cancer Registry (KCR) for all Kuwaiti children (0-14 years) and adults (15-99 years) diagnosed with one of 18 common cancers during 2000-2013, with follow-up for vital status to 31 December 2015. World-standardised average annual incidence and mortality rates were calculated for 2000-2004, 2005-2009, 2010-2013.

CXCR4 as a novel target in immunology: moving away from typical antagonists.

CXCR4 has been a target of interest in drug discovery for numerous years. However, so far, most if not all studies focused on finding antagonists of CXCR4 function. Recent studies demonstrate that targeting a minor allosteric pocket of CXCR4 induces an immunomodulating effect in immune cells expressing CXCR4, connected to the TLR pathway.

Spatial distribution and interannual variability of cyanobacteria blooms on the North-Western shelf of the Black Sea in 1985-2019 from satellite data.

Long-term high and medium resolution satellite data are used to study spatial, seasonal and interannual variability of the cyanobacteria blooms (CB) in the North-Western Shelf (NWS) of the Black Sea. High-resolution Landsat data demonstrate that CB were regularly observed in the study area on satellite images in 1985-2020. Comparison of quasi-synchronous Landsat and MODIS images was used to study the characteristic features of CB spectra, which are: a "step" formed by MODIS 3 (469) and 4 (488) channel, probably related to the absorption by photoprotective carotenoids; increased reflectance in near-infrared; maximum at 547-555 nm.