Publications by authors named "A van Sighem"
Men who have sex with men (MSM) are disproportionally affected by HIV in the Netherlands. Partner notification (PN) is an important element in controlling the transmission of sexually transmitted infections (STIs) and HIV. We investigated the effects of improving PN on the transmission of HIV and (NG) among MSM in the Netherlands.
View Article and Find Full Text PDFHarmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration.
Alcohol Clin Exp Res (Hoboken)
January 2025
Background: Alcohol use is measured in diverse ways across settings. Harmonization of measures is necessary to assess effects of alcohol use in multi-cohort collaborations, such as studies of people with HIV (PWH).
Methods: Data were combined from 14 HIV cohort studies (nine European, five North American) participating in the Antiretroviral Therapy Cohort Collaboration.
Article Synopsis
- In the Netherlands, since the introduction of HIV pre-exposure prophylaxis (PrEP) in 2019, about 16% of new HIV diagnoses among men who have sex with men (MSM) and transgender persons (TGP) reported prior PrEP use.
- Many individuals who did not use PrEP cited reasons like low risk perception and lack of access, highlighting barriers to its uptake.
- The study identified an increase in PrEP-associated mutations linked to resistance in new infections since 2019, but found no evidence of these mutations being transmitted to others.
Background: Understanding the reasons for and consequences of bodyweight change in people living with HIV initiating antiretroviral therapy (ART) is crucial to optimising long-term health and wellbeing. We aimed to examine bodyweight trends and associated factors among individuals with well estimated dates of HIV-1 seroconversion.
Methods: In this cohort study, we pooled retrospective data from clinical records of participants in CASCADE aged 16 years and older recruited from clinics in France, Greece, the Netherlands, Spain, Sweden, the UK, and Canada.
Background: In 2019, a 5-year pre-exposure prophylaxis (PrEP) program started in the Netherlands, in which up to 8500 men who have sex with men (MSM) can obtain PrEP and 3-monthly consultations with HIV/STI testing.
Setting: We assessed the impact of the PrEP program on transmission of HIV and Neisseria gonorrhea (NG) among MSM in the Netherlands and examined prospective variations of the program after 2024.
Methods: We used an agent-based model to estimate the effect of the PrEP program.