Publications by authors named "A van Hylckama-Vlieg"
Robust metabolomic age prediction based on a wide selection of metabolites.
J Gerontol A Biol Sci Med Sci
January 2025
Chronological age is a major risk factor for numerous diseases. However, chronological age does not capture the complex biological aging process. the difference between the chronological age and biologically driven aging could be more informative in reflecting health status.
View Article and Find Full Text PDFVenous thromboembolism (VT) is a frequent (annual incidence of 1 to 2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VT is associated with serious short-term and long-term complications including a recurrence rate of approximately 20% within five years. Anticoagulant therapy, the mainstay of VT treatment, drastically reduces the risk of early VT recurrence, but it exposes patients to a substantial risk of bleeding.
View Article and Find Full Text PDFObjectives: Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, randomized controlled trials BCG-PRIME (n = 5349) and BCG-CORONA-ELDERLY (n = 1907) investigated the impact of BCG on SARS-CoV-2 infections in older individuals. We extended the follow-up in these studies by one year (BCG-Long Term study), to assess the overall effects of BCG vaccination on infectious and immune-mediated diseases in individuals aged over 60.
View Article and Find Full Text PDFArticle Synopsis
- Factor V (FV) is crucial for the blood coagulation process, and its plasma levels are linked to various health issues like blood clots and diabetes.
- The researchers used a specific statistical method called the Brown-Forsythe methodology to analyze genetic factors affecting FV levels in 4505 individuals from four different studies.
- They identified a significant genetic variant (rs75463553) associated with the variability in FV plasma levels, highlighting the interaction between neutrophil-related genes and FV biology.
Article Synopsis
- Hypercoagulability is linked to higher levels of coagulation factors and increased thrombin generation, which could be related to type 2 diabetes and other complications like glucose metabolism issues and endothelial dysfunction.
- The study analyzed data from 5,718 participants, tracking diabetes diagnoses over 6.7 years, and found that higher levels of specific coagulation factors correlated with increased risk of developing type 2 diabetes.
- Although glycoprotein acetylation (GlycA) was examined as a potential mediator in these associations, it only explained a small portion of the relationship, suggesting that hypercoagulability plays a significant role in the development of type 2 diabetes.