Advance Care Planning Billing Codes Associated With Decreased Healthcare Utilization in Neurological Disease.

Goals: Advance care planning (ACP) procedure codes have been established to reimburse meaningful care goal discussions; however, the utilization frequency of these codes in neurological disease is unknown. The objective of this study is to identify the association between ACP codes and healthcare utilization in chronic neurodegenerative diseases.

Methods: This is a multicenter cohort study using real-world electronic health data.

Identification of phosphatases that dephosphorylate the co-chaperone BAG3.

The co-chaperone BAG3 plays critical roles in maintaining cellular proteostasis. It associates with 14-3-3 proteins during the trafficking of aggregation-prone proteins and facilitates their degradation through chaperone-assisted selective autophagy in cooperation with small heat shock proteins. Although reversible phosphorylation regulates BAG3 function, the involved phosphatases remain unknown.

Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic.

Proteome maintenance in contracting skeletal and cardiac muscles depends on the chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and heart failure in animal models and patients. BAG3 and its chaperone partners recognize mechanically damaged muscle proteins and initiate their disposal through chaperone-assisted selective autophagy (CASA).

Crack width and crack spacing in reinforced and prestressed concrete elements: Data description and acquisition.

Existing databases containing measurements of crack width and spacing are usually limited in size and based on isolated experimental studies. These databases are used to develop new formulas to describe crack patterns in concrete structures. A database obtained from multiple sources of experimental programmes is required to quantify the accuracy of those formulas.