Background: Part of the people who radicalize suffer from psychiatric symptoms and some of the people who resort to extremist violence have previously been in contact with mental health services. The question is how psychopathological characteristics can influence radicalization and what mental health professionals can do about this.
Aim: Provide insight into the interaction between psychopathology, radicalization, extremism and how mental health professionals can integrate vulnerabilities into treatment.
Objectives: Mycoplasma genitalium, a sexually transmitted bacterium, faces increasing antibiotic resistance, particularly to azithromycin. However, presence of macrolide resistance-associated mutations (MRAMs) does not evidently implicate azithromycin treatment failure. This study aimed to establish an in vitro co-culture system of M.
View Article and Find Full Text PDFThe hydrogen-bond donor strength of ureas, widely used in hydrogen-bond donor catalysis, molecular recognition, and self-assembly, can be enhanced by increasing the size of the chalcogen X in the CX bond from O to S to Se and by introducing more electron-withdrawing substituents because both modifications increase the positive charge on the NH groups which become better hydrogen-bond donors. However, in 1,3-diaryl X-ureas, a steric mechanism disrupts the positive additivity of these two tuning factors, as revealed by our quantum-chemical analyses. This leads to an enhanced hydrogen-bond donor strength, despite a lower NH acidity, for 1,3-diaryl substituted O-ureas compared to the S- and Se-urea analogs.
View Article and Find Full Text PDF