[The same agent, no response upon restart: tachyphylaxis with psychotropic medications].

Background: This scoping review focuses on the occurrence of tachyphylaxis, defined as reduced responsiveness upon reinitiating a previously effective medication. This phenomenon is previously documented in antidepressants and mood stabilizers.

Aim: To explore the frequency, treatment strategies, and predictability of tachyphylaxis across all psychotropic medications.

Syndromic Retinitis Pigmentosa.

Retinitis pigmentosa (RP) is a progressive inherited retinal dystrophy, characterized by the degeneration of photoreceptors, presenting as a rod-cone dystrophy. Approximately 20-30% of patients with RP also exhibit extra-ocular manifestations in the context of a syndrome. This manuscript discusses the broad spectrum of syndromes associated with RP, pathogenic mechanisms, clinical manifestations, differential diagnoses, clinical management approaches, and future perspectives.

A Surface-Active Pt(II) Bis-N-Heterocyclic Carbene (NHC) Complex for Interface-Enhanced Supported Ionic Liquid Phase (SILP) Catalysis.

We present the preparation and investigation of a fluorine-free surface-active bis-N-heterocyclic carbene (NHC) platinum(II) complex - trans-[Pt(mPEGCIm)Cl] - for interface-enhanced supported ionic liquid phase (SILP) catalysis within a group of (mPEG)-substituted ionic liquids (ILs) ([(mPEG)Im][A] ILs). The complex was characterized by means of single-crystal X-ray diffraction (scXRD) analysis and multinuclear (H, C, Pt) NMR spectroscopy, indicating the presence of two almost equimolar syn-anti-rotamers of the square-planar complex in solution. Angle-resolved X-ray photoelectron spectroscopy (ARXPS) revealed pronounced interface-accumulation of trans-[Pt(mPEGCIm)Cl] in IL solutions of [(mPEG)Im][A] (A=I and PF ).

Fish and shellfish allergy: Presentation and management differences in the UK and US-analysis of 945 patients.

Background: Seafood allergy (SA), including allergy to shellfish (crustacean and mollusks) and fish, is among the 4 most common food allergies causing anaphylaxis, but there are limited data showing SA clinical management in different countries.

Objective: We sought to characterize a large cohort of patients with fish and shellfish allergy and to facilitate standardization of future care for this increasingly common allergic disease.

Methods: We performed a retrospective, observational, noninterventional study from 945 patients from 2015 to 2019 in 7 hospitals in the United States and the United Kingdom to evaluate SA.