Clinical and molecular spectrum of TK2-deficiency: a large Brazilian cohort.

Biallelic pathogenic variants at TK2 lead to a severe and progressive myopathy (TK2d). For a disease with unspecific clinical findings, and the possibility of a supplementation therapy that changes the natural history of the disease, highlighting clinical features that increase suspicion and accelerate diagnosis is essential. Clinical and genetic findings of 36 Brazilian patients with TK2d were identified and presented in this work.

Inclusion of yeast and saccharides based-product to replace monensin in the diet of confined steers: performance, rumen environment, metabolism, animal health, and meat quality.

The present study aimed to evaluate a blend of yeast and saccharides based-product fed via diet to feedlot cattle on performance, health, meat quality, and rumen metabolism when compared to monensin. Twenty-four non-castrated crossbred male steers (Charolais x Nellore) were divided into control (n = 12), receiving the basal diet with monensin (215 mg/animal/day) and treatment (n = 12) receiving the basal diet with the blend of yeast and saccharides based-product (17.2 g/animal/day).

From waste to wellness - what women want: insights into patient perspectives on topical vaginal estrogen applicators and environmental considerations.

Objective: Environmental consciousness and the role of plastic waste are increasing. Topical vaginal estrogen prescription can be prescribed with one reusable plastic applicator or multiple single-use plastic applicators. User preference about the role of plastic in personal healthcare is not fully understood.

Does Mental Fatigue Affect Physical Performance in Wheelchair Basketball Players? An Individualized Cognitive Load Approach.

The negative effects of mental fatigue on physical performance have been well established in different sports that require aerobic endurance, but, in this study, we investigated the impact of mental fatigue on the physical performance of paralympic (wheelchair basketball) athletes. Eleven participants completed a baseline and two experimental sessions, each separated by 24 hours. The baseline session familiarized participants with the measurements.