Publications by authors named "A de Nisi"
After the near-complete cessation of commercial whaling, ship collisions have emerged as a primary threat to large whales, but knowledge of collision risk is lacking across most of the world's oceans. We compiled a dataset of 435,000 whale locations to generate global distribution models for four globally ranging species. We then combined >35 billion positions from 176,000 ships to produce a global estimate of whale-ship collision risk.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest neoplasms in the world. Although various advancements in the treatment and management of this disease have been made, no significant overall survival benefit has been achieved. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has been proposed as a treatment for patients who are unfit for surgery or with inoperable PDAC.
View Article and Find Full Text PDFExcess inflammation and oxidative stress are common themes in many pathologies of pregnancy including preeclampsia and more recently severe COVID-19. The risk of preeclampsia increases following maternal infection with COVID-19, potentially relating to significant overlap in pathophysiology with endothelial, vascular and immunological dysfunction common to both. Identifying a therapy which addresses these injurious processes and stabilises the endothelial and vascular maternal system would help address the significant global burden of maternal and neonatal morbidity and mortality they cause.
View Article and Find Full Text PDFContext: The glucagon-like peptide-1 receptor (GLP-1R) agonist semaglutide (SEMA) produces 15% weight loss when chronically administered to humans with obesity.
Methods: In 2 separate experiments, rats received daily injections of either vehicle (VEH) or SEMA starting at 7 µg/kg body weight (BW) and increasing over 10 days to the maintenance dose (70 µg/kg-BW), emulating clinical dose escalation strategies.
Results: During dose escalation and maintenance, SEMA rats reduced chow intake and bodyweight.
The ecology of human-caused mortality for a protected large carnivore.
Proc Natl Acad Sci U S A
March 2023
Article Synopsis
- The study focuses on human-caused mortality in mountain lions across California, finding that this type of mortality is more significant than natural causes, despite legal protections against hunting.
- Researchers determined that human-caused mortality is additive to natural mortality, meaning it worsens population survival rather than just compensating for natural deaths.
- The risk of mortality for mountain lions is influenced by human development and community attitudes toward conservation, highlighting the importance of human impact on wildlife survival.