Evolutionary rescue via niche construction: Infrequent construction can prevent post-invasion extinction.

A population experiencing habitat loss can avoid extinction by undergoing genetic adaptation-a process known as evolutionary rescue. Here we analytically approximate the probability of evolutionary rescue via a niche-constructing mutation that allows carriers to convert a novel, unfavorable reproductive habitat to a favorable state at a cost to their fecundity. We analyze competition between mutants and non-niche-constructing wild types, who ultimately require the constructed habitats to reproduce.

Development and co-construction of a therapeutic patient education program for albinism.

Background: Long-term and ongoing support in accordance with the changing needs of patients and their families is one of the main components of patient care, including therapeutic patient education (TPE).

Objective: To co-construct a TPE program for albinism with all those involved in the management of albinism patients.

Methods: Eight steps have been defined for the co-construction process: 1) identify all the relevant experts and invite them to participate in the construction of a TPE program to improve care for and support of patients with albinism, 2) review and analyse all publications regarding TPE for albinism, 3) conduct semi-structured interviews with the patients' parents, 4) conduct brainstorming meetings with the participating experts for an exchange of experience and expertise, 5) elaborate the program's concrete content with the experts, 6) draw up a TPE skills checklist, 7) create TPE educational tools to facilitate learning, 8) review and summarize each step of the co-construction protocol.

Hydrolysis of factor VIII mediated by catalytic antibodies occurs in haemophilia A patients with or without factor VIII inhibitors.

The major complication of the substitutive treatment of haemophilia A (HA) is the development of antifactor VIII (FVIII) antibodies. Most of these antibodies neutralize FVIII procoagulant activity, and are identified as FVIII inhibitor. A subgroup of these antibodies, 'catalytic antibodies', catalyses the FVIII hydrolysis.