Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population.

Introduction: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events.

Objective: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO).

Method: 1.

Performance evaluation of a two-stage few-mode EDFA for high-capacity SDM systems.

Space division multiplexing (SDM) systems using few-mode fibers (FMF) are essential for next-generation fiber optic communications. Optical amplifiers with low noise, minimal differential modal gain (DMG), and minimal differential spectral gain (DSG) are essential for these systems. In this work, we present a method to design and optimize a two-stage few-mode erbium-doped fiber amplifier (FM-EDFA) using a joint DMG-DSG minimization approach.

The autophagy process and oxidized LDL independently modulate the invasion and differentiation of extravillous trophoblastic cells to an endothelial-like phenotype in normoxia.

Introduction: The mechanisms leading to proper placentation are not fully understood. Extravillous trophoblasts (EVTs) are crucial for placentation through invasion and vascular remodeling, which, when impaired, promote a poor placentation. How autophagy could regulate EVTs function and the study of regulators of these processes, such as oxidized low-density lipoproteins (ox-LDL), could contribute to better understand events associated with pregnancy complications related to abnormal placental development, such as preeclampsia (PE).

Evaluation of the effectiveness of cognitive-behavioural therapy for insomnia delivered by nurses and physicians for patients in primary care (the NPD study): protocol for a cluster randomised controlled trial.

Introduction: Insomnia is the most common sleep disorder, and it adversely impacts daily living and increases the risk of chronic and acute health problems. Of the few individuals who seek treatment for insomnia, most pursue help in primary care settings. The management of insomnia most commonly focuses on the prescription of hypnotics and sleep hygiene recommendations, although these are not the most effective treatments.