Benefit-risk assessment based on number needed to treat and number needed to harm: Atogepant vs. calcitonin gene-related peptide monoclonal antibodies.

Background: To evaluate the benefit-risk assessment of atogepant and calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) vs. placebo based on the number needed to treat (NNT) and the number needed to harm (NNH) in a blended episodic migraine and chronic migraine (EM + CM) population.

Methods: The NNT was calculated based on achievement of a ≥ 50% reduction in mean monthly migraine days (MMDs) from baseline across 12 weeks.

Cost per treatment responder analysis of atogepant compared to rimegepant for the preventive treatment of episodic migraine.

Objective: To estimate the number needed to treat and cost per additional responder for atogepant and rimegepant versus placebo for the preventive treatment of episodic migraine (EM) in the United States.

Background: Migraine has an enormous impact on a person's daily activities and quality of life, and results in significant clinical and economic burden to both individuals and society. It is important to understand the comparative efficacy and economic value of oral calcitonin gene-related peptide receptor antagonists (gepants) for preventive treatment of EM.

Impact of lifestyle and dietary modifications for endometriosis development and symptom management.

Purpose Of Review: Management of endometriosis is often complex and poorly studied. Patients with endometriosis have interest in how their lifestyle may affect their diagnosis. Self-management and lifestyle changes are often used as adjunct therapy, but best practices are not concrete in treatment guidelines.

Considerations for Contraception Following Spinal Cord Injury: A Systematic Review.

Introduction: Counseling and education on women's health, specifically contraception, following spinal cord injury (SCI) is an important component of care for women with SCI. While a plethora of available contraceptive options exists, research in this area is scarce.

Objectives: This systematic review assesses the quality and quantity of research on contraception for individuals with SCI.

Spectrogram Inversion for Reconstruction of Electric Currents at Industrial Frequencies: A Deep Learning Approach.

In this paper, we present a deep learning approach for identifying current intensity and frequency. The reconstruction is based on measurements of the magnetic field generated by the current flowing in a conductor. Magnetic field data are collected using a magnetic probe capable of generating a spectrogram, representing the spectrum of frequencies of the magnetic field over time.