Publications by authors named "A Zuppiroli"

Background And Aims: Lowering low-density lipoprotein cholesterol (LDL-C) is the cornerstone of cardiovascular disease prevention. Collection of epidemiological data is crucial for monitoring healthcare appropriateness. This analysis aimed to evaluate the proportion of high-risk patients who achieved guidelines recommended LDL-C goal, and explore the predictors of therapeutic failure, with a focus on the role of gender.

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Article Synopsis
  • The study examined the effectiveness of three antiviral treatments for early COVID-19 (nirmatrelvir/ritonavir, molnupiravir, and remdesivir) among a large group of outpatient patients.
  • 1,342 patients were analyzed, with high clinical recovery rates (96.9%) and a low hospitalization rate (2.6%), showing no significant differences in outcomes between the antiviral treatments.
  • Vaccination status was important, as vaccinated patients had a lower risk of hospitalization or death compared to unvaccinated individuals.
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Background: People who inject drugs (PWID) and homeless people represent now a large reservoir of Hepatitis C virus (HCV) infection. However, Hepatis C elimination programs can barely reach these subgroups of patients. We aimed to evaluate and compare the retention in care among these difficult-to-treat patients when managed for HCV in hospital or in an out-of-hospital setting.

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Article Synopsis
  • - The study investigates the impact of chronic diseases on the risk of developing mild to symptomatic COVID-19 infections in the Toscana Centro region, where significant case numbers were reported during the pandemic.
  • - It analyzes data from 1,840 confirmed cases, highlighting that older males and individuals with chronic conditions such as heart failure and psychiatric disorders are at a significantly higher risk of severe symptoms related to SARS-CoV-2.
  • - Findings indicate that having a chronic disease increases a person's risk of symptomatic COVID-19 by 68%, emphasizing the need for further research on chronic illness factors in managing pandemic responses.
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