Publications by authors named "A Zuk"
Article Synopsis
- Supramolecular ECM networks, crucial for skin structure and function, include EMILIN proteins that interact with elastin and influence cellular signaling.
- Our study mapped the distribution of EMILIN-1, -2, and -3 in human skin, revealing their role in elastic fibers and their connections with basal keratinocytes.
- We found that in conditions like Marfan syndrome and scleroderma, the presence and localization of EMILINs change, indicating they can be used as markers for monitoring dermal ECM rearrangements due to aging and disease.
Background: The autonomic nervous system (ANS) plays a significant role in atrial fibrillation (AF). Catheter ablation (CA) is a well-established treatment method for AF and significantly affects the ANS, including baroreceptor (BR) function. However, little is known about the changes in BR function caused by radiofrequency (RF) or cryoballoon energy (CB) and its impact on future AF recurrences.
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- Fort Albany First Nation (FAFN) created a buprenorphine-naloxone program to combat opioid use issues that worsened during the COVID-19 pandemic, developed by local nurses and community leaders.
- The study used qualitative methods and oral narratives, focusing on discussions with community leaders to highlight strengths and challenges through a holistic framework addressing well-being.
- Key recommendations include hiring culturally competent staff, tailoring educational programs, increasing funding, and recognizing the importance of community leadership in implementing effective opioid crisis solutions.
Introduction: Geese harvesting is a longstanding cultural tradition deeply ingrained among the Omushkego Cree in Fort Albany First Nation, embodying a holistic approach to health that integrates Indigenous knowledge, community wellbeing, and resilience. Despite historical disruptions stemming from colonization and assimilation policies, women have played a pivotal role in preserving and passing down traditional practices. The significance of goose harvesting extends beyond providing a nutrient-rich and cost-effective food source; it serves as a vehicle for cultural preservation and education, particularly fostering language acquisition among children.
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- Vadadustat is an oral medication being researched for treating anemia in patients with chronic kidney disease (CKD) by inhibiting a specific enzyme involved in oxygen regulation.
- The studies involved healthy volunteers receiving varying doses of vadadustat to assess how the drug is processed in the body (pharmacokinetics), its effects (pharmacodynamics), and safety.
- Results showed that vadadustat increased levels of erythropoietin (EPO), a hormone that stimulates red blood cell production, and had mild side effects, supporting its potential for treating CKD-related anemia.