Publications by authors named "A Zucker"
Nearly all pancreatic adenocarcinomas (PDAC) are genomically characterized by KRAS exon 2 mutations. Most patients with PDAC present with advanced disease and are treated with cytotoxic therapy. Genomic biomarkers prognostic of disease outcomes have been challenging to identify.
View Article and Find Full Text PDFWe examined the effect of habitual preexercise caffeine supplementation on training-induced adaptations to exercising systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), heart rate (HR), and double product (DP). Young women (means ± SD; 24 ± 7 yr) were randomized to a caffeine (120 mg) supplement (CAF; = 17) or placebo (PLA; = 16) group, completed 6 wk of high-intensity exercise training on three nonconsecutive days per week, and supplemented with CAF or PLA 30-60 min before exercise or else upon waking. Before (PRE) and after (POST) the intervention, SBP, DBP, and HR were measured and PP and DP were calculated, at rest and during fixed-power exercise at 50 and 75 W.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied 91 cases of pancreatic cancer to understand how the DNA changes in these cancers and what that means for patients.
- They found that having a lot of mutations in the cancer's early development was linked to shorter survival times.
- Different types of tumors showed varying patterns in how they spread and changed, which means pancreatic cancer can act in more than one way in patients.
Importance: Data from surveys show increased mental health disorders in youths. However, little is known about clinical diagnosis over time.
Objective: To assess the incidence, prevalence, and changes from 2017 to 2021 for depression and anxiety diagnosed clinically among children, adolescents, and young adults and to identify potential disparities.
Purpose: We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.
Methods: Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE) or 1200 mg (GLE) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing.