Publications by authors named "A Zou"
Article Synopsis
- The study addresses the challenge of varying economic traits in sea cucumber aquaculture by comparing gene expression and networks to find key genes related to morphological differences in Apostichopus japonicus.
- Researchers identified three important genes linked to better economic traits and discovered specific SNPs in the ficolin-2 gene that correlate with two traits: body weight and papilla number.
- These findings aim to enhance breeding strategies and biomarker resources, promoting advancements in molecular-assisted breeding for sea cucumbers.
Nickel-based hydroxides [Ni(OH)] have attracted significant attention as effective oxygen evolution reaction (OER) catalysts. In recent years, defect engineering has been extensively utilized in Ni(OH) modification research. Numerous studies have confirmed that the generation of defects can expose more active sites and regulate electronic states, particularly through the introduction of Al cationic vacancies, which enhance conductivity and thereby improve the catalytic performance.
View Article and Find Full Text PDFBy virtue of its role in cellular proliferation, microtubule-associated serine/threonine kinase-like (MASTL) represents a novel target and a first-in-class (FIC) opportunity to provide a new impactful therapeutic agent to oncology patients. Herein, we describe a hit-to-lead optimization effort that resulted in the delivery of two highly selective MASTL inhibitors. Key strategies leveraged to enable this work included structure-based drug design (SBDD), analysis of lipophilic efficiency (LipE) and novel synthesis.
View Article and Find Full Text PDFCa2+ signaling via the store operated Ca2+ entry (SOCE) mediated by STIM1 and STIM2 proteins and the ORAI1 Ca2+ channel is important in saliva fluid secretion and has been associated with Sjogren's disease (SjD). However, there are no studies addressing STIM1/2 dysfunction in salivary glands or SjD in animal models. We report that mice lacking Stim1 and Stim2 (Stim1/2K14Cre(+)) in salivary glands exhibited reduced Ca2+ levels and hyposalivate.
View Article and Find Full Text PDFArticle Synopsis
- * The condition is caused by mutations in the LYST gene, illustrated in a case study where a child showed symptoms such as pale skin and significant blood abnormalities like pancytopenia.
- * Treatment involved allogeneic hematopoietic stem cell transplantation along with umbilical cord blood transplantation, leading to success as the patient remained healthy for nine months post-treatment, indicating this approach's effectiveness.