Irreversible incorporation of L-dopa into the C-terminus of α-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon.

L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias. Despite extensive research on L-dopa-induced dyskinesia, its pathogenesis remains poorly understood.

Experience with the long-term effect of microsurgical penile revascularization.

Fourty-two consecutive men underwent microsurgical penile revascularization for arterial insufficiency at least one year prior to this review. Data on the results of surgery were collected by questionnaire or telephone in 33 men (79%) with complete follow-up and by chart review in 9 men (21%) with partial follow-up. Success was measured as the ability to achieve successful intercourse on the majority of attempts without adjuvant therapy.

Experience with buccal phentolamine mesylate for impotence.

Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papaverine HCl for intracavernous injection. The previous observation by Gwinup, that 50 mg of phentolamine HCl po, 1.