Publications by authors named "A Zmyslowska"
-spectrum disorders are caused by a mutation in the gene. The term includes a wide range of rare disorders, from the most severe Wolfram syndrome with autosomal recessive inheritance to milder clinical manifestations with a single causative variant in the gene, such as Wolfram-like syndrome, low-frequency sensorineural hearing loss (LFSNHL), isolated diabetes mellitus (DM), nonsyndromic optic atrophy (OA), and isolated congenital cataracts. The aim of this study was to evaluate genotype-phenotype correlations in Polish patients with -spectrum disorders.
View Article and Find Full Text PDFIntense exercise leads to neutrophil extracellular traps (NETs) formation, which triggers cell disintegration. NET, as well as other processes of apoptosis, necrosis, and spontaneous secretion, result in increased levels of cell-free DNA (cf-DNA) in the circulation. An increment of cf-DNA is also observed in autoimmune diseases, such as type 1 diabetes mellitus (T1DM).
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- Curcumin, derived from turmeric, has known anti-inflammatory and antioxidant benefits and is being researched for its potential protection against ethanol-induced developmental issues during pregnancy, like fetal alcohol syndrome (FAS).
- Recent studies have focused on how curcumin might mitigate ethanol's harmful effects in animal models, particularly in zebrafish embryos.
- However, findings revealed that curcumin did not prevent malformations from ethanol exposure in zebrafish, and in some cases, it even showed a pro-oxidant effect when combined with ethanol.
Article Synopsis
- This study assessed the effectiveness of Continuous Glucose Monitoring (CGM) in adults with insulin-dependent diabetes due to Wolfram syndrome (WFS) compared to those with type 1 diabetes (T1D).
- Ten adults with WFS were monitored over 14 days and showed significantly lower average glucose levels and glycemic variability than 30 matched T1D patients.
- Results indicated that WFS patients experienced less time in high-range hyperglycemia and had more stable blood sugar levels overall, suggesting different glycemic control dynamics in WFS compared to T1D.
Purpose: Monogenic diabetes (MD) is caused by a mutation in a single gene and accounts for approximately 2.5-6% of all diabetes cases. Maturity-onset diabetes of the young (MODY) is the most common form of MD.
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