Synthesis and characterization of metal dithiocarbamate derivatives of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline.

Five metal dithiocarbamate complexes [M(PTHIQDTC)] [where PTHIQDTC is (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate anion and M is Ni(II) (1), Sn(II) (2), Hg(II) (3), Pb(II) (4) and Zn(II) (5)] were synthesized from the reaction of MX (X is Cl for 1-3 and OAc for 4-5) with ligand of triethylammonium (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate [EtNH][PTHIQDTC] in methanolic solution at room temperature. The five complexes were characterized by IR, H andC NMR, mass spectrometry, elemental analysis and TGA analysis. Recrystallization of [Zn(PTHIQDTC)] (5) in dimethylsulfoxide (DMSO) converts 5 to [Zn(PTHIQDTC)(DMSO)] (6).

Synthesis of bisnitroepoxides and their applications in the synthesis of bis(thiazolidine-2-thiones), bis(dithiocarbamates), bis(xanthates) and bis(thiazoles).

Novel bis(nitroepoxides) were prepared based on terephthaldehyde and isophthaladehyde and their reactions with diversities of nucleophiles such as primary and secondary amine-based dithiocarbamic acids, xanthates, and ammonia-based dithiocarbmamates were investigated for the synthesis of bis(thiazolidine-2-thiones), bis(dithiocarbamates), bis(xanthates) and bis(thiazoles), respectively. It provides simple access to complex molecules in one step in high to excellent yields.

Rhodium-catalyzed diastereoselective synthesis of highly substituted morpholines from nitrogen-tethered allenols.

Rhodium-catalyzed intramolecular cyclization of nitrogen-tethered allenols was investigated for the synthesis of functionalized morpholines. By using this strategy, various -protected 2,5- and 2,6-disubstituted as well as 2,3,5- and 2,5,6-trisubstituted morpholines were obtained an atom-economic pathway with high to excellent yields, diastereo- and enantioselectivities (up to 99% yield, up to >99 : 1 dr and up to >99.9 ee).

Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach.

A metal-free multicomponent synthetic route for the diverse preparation of dithiocarbamate-containing piperazine derivatives was developed through the C-N bond cleavage of DABCO ring. This multicomponent re-engineering approach proceeds the reaction of amines, CS and DABCO salts in one pot. Various DABCO salts and secondary amines are tolerated well in this protocol to afford a broad spectrum of dithiocarbamate-containing piperazines in good to high yields.

DABCO bond cleavage for the synthesis of piperazine derivatives.

The applications of DABCO (1,4-diazabicyclo[2.2.2]octane) in the synthesis of piperazine derivatives including biologically active compounds C-N bond cleavage are investigated in this review.