Publications by authors named "A Zirakzadeh"
B cells are multifaceted immune cells responding robustly during immune surveillance against tumor antigens by presentation to T cells and switched immunoglobulin production. However, B cells are unstudied in prostate cancer (PCa). We used flow cytometry to analyze B-cell subpopulations in peripheral blood and lymph nodes from intermediate-high risk PCa patients.
View Article and Find Full Text PDFWe studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells.
View Article and Find Full Text PDFPurpose: Nearly half of penile cancers are related to human papillomavirus (HPV) infection. Investigations of tumor- and HPV-specific T cell reactivity in regional lymph nodes (LNs) from patients with penile cancer are warranted.
Materials And Methods: In this study, single-cell suspensions from LNs and peripheral blood from 11 patients with penile cancer were stained with antibodies for lymphocyte markers and analyzed by fluorescence-activated cell sorting (FACS).
Tumour infiltrating B cells and CD38 plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL-10 is a multifunctional cytokine with both anti-inflammatory and immunostimulatory properties, that can be released by regulatory B cells (Bregs). We have stained paraffin-embedded tumour sections from 31 patients with invasive urothelial urinary bladder cancer with respect to CD20 B cells, CD38 cells, IL-10-expressing cells, IgG, C1q and C3a and analysed the impact of these markers on survival.
View Article and Find Full Text PDFArticle Synopsis
- Urinary bladder cancer is a prevalent cancer influenced by environmental factors and inflammation, diagnosed mainly through surgery, with treatment options including cystectomy and chemotherapy.
- This study focused on the immune responses of CD4 T cells in the tumor, lymph nodes, and blood, examining how different signs of lineage commitment relate to disease stage and chemotherapy response.
- Findings showed that CD4 T cells in tumors had less methylation compared to those in lymph nodes and blood, indicating potential biomarkers for survival and treatment effectiveness in bladder cancer patients.