Publications by authors named "A Zick"
Article Synopsis
- * Researchers analyzed cell-free DNA (cfDNA) from blood samples of a patient with HER2-positive endometrial cancer who developed ILD, as well as samples from other patients, to detect lung damage through specific methylation markers.
- * The findings suggest that liquid biopsy, an easy and cost-effective method, could effectively monitor ADC-related ILD, potentially offering a better alternative to traditional imaging techniques.
Background: The carcinogenicity of air pollution and its impact on the risk of lung cancer is well known; however, there are still knowledge gaps and mixed results for other sites of cancer.
Methods: The current study aimed to evaluate the associations between ambient air pollution [fine particulate matter (PM2.5) and nitrogen oxides (NOx)] and cancer incidence.
TP53 pathogenic variants cause Li-Fraumeni syndrome (LFS), with some variants causing an attenuated phenotype. Herein, we describe the clinical phenotype and genetic characteristics of carriers of NM_000546.6 (TP53): c.
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- Scientists are looking for better ways to detect pancreatic cancer early so it can be treated more effectively.
- They studied blood samples from 426 patients to find different markers that could indicate pancreatic cancer compared to other conditions.
- Results showed that a mix of certain protein markers and DNA changes in the blood can help identify early-stage pancreatic cancer better than just using one marker alone.
Background: Radiotherapy has an important role in the treatment of brain metastases but carries risk of short and/or long-term toxicity, termed radiation-induced brain injury (RBI). As the diagnosis of RBI is crucial for correct patient management, there is an unmet need for reliable biomarkers for RBI. The aim of this proof-of concept study is to determine the utility of brain-derived circulating free DNA (BncfDNA), identified by specific methylation patterns for neurons, astrocytes, and oligodendrocytes, as biomarkers brain injury induced by radiotherapy.
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