Publications by authors named "A Zh Abdrakhmanov"

This prospective study evaluates the impact of radiofrequency ablation (RFA) on cardiorespiratory indicators in patients with long-standing persistent atrial fibrillation admitted to the Heart Center UMC between January 2022 and April 2024 in Astana, Kazakhstan. The study aims to assess the functional cardiac benefits of RFA. Out of 717 registered atrial fibrillation patients, 104 were examined before and 3 months after ablation, focusing on cardiorespiratory parameters.

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Introduction: The reduction of fluoroscopic exposure during catheter ablation of supraventricular arrhythmias is widely adopted by experienced electrophysiology physicians with a relatively short learning curve and is becoming the standard of care in many parts of the world. While observational studies in the United States and some parts of Western Europe have evaluated the minimal fluoroscopic approach, there are scarce real-world data for this technique and the generalizability of outcomes in other economic regions.

Method: The AALARA study is a prospective, observational, multicenter, and multinational open-label study.

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Article Synopsis
  • The study investigates how genetic variations in certain genes affect the metabolism and effects of the blood thinner dabigatran in patients with atrial fibrillation.
  • Using TaqMan technology, the research analyzed genotypes from 150 patients and found significant differences in dabigatran concentrations based on specific gene polymorphisms.
  • The findings suggest that polymorphisms rs8192935 and rs2244613 influence dabigatran's pharmacodynamics and pharmacokinetics, particularly in the Kazakh population.
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Article Synopsis
  • * This review focuses on the pharmacokinetics, pharmacodynamics, and genetic factors (such as gene polymorphisms) that influence the effectiveness and safety of DOACs, analyzing data from various databases and studies.
  • * Findings suggest that genetic variations affect how individuals metabolize DOACs, which could lead to personalized treatment plans to reduce complications; however, further large-scale studies are needed to better define dosing
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Colloidal suspensions of EuCl, EuBr, and EuSO nanoparticles (<50 nm) in dodecane and EuSO in 70% HSO were synthesized. Moving single-bubble sonoluminescence (m-SBSL) spectra were obtained for a bubble performing radial oscillations in these suspensions and translational motions at the antinode of a standing ultrasonic wave with a frequency of about 27 kHz. In these spectra (at a spectral resolution of 10 nm), the sono-excited luminescence bands of the Eu ion were detected for the first time, coinciding in the shape and position of the maxima (404, 413, and 377 nm for EuCl, EuBr, and EuSO, respectively) with the bands of Eu located in a crystalline environment in the photoluminescence spectra of nanoparticles of europium salts in suspensions.

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