Publications by authors named "A Zeleniuch-Jacquotte"

Purpose: To examine the association between cumulative exposure to neighborhood walkability (NW) and diabetes risk.

Methods: A total of 11,037 women free of diabetes at enrollment were included. We constructed a 4-item NW index at baseline, and a 2-item average annual NW across years of follow-up that captured both changes in neighborhood features and residential moves.

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Article Synopsis
  • The American Cancer Society suggests that doctors should talk to women about endometrial cancer risks when they reach menopause, but more younger women under 50 are being diagnosed.
  • A study looked at nearly 14,000 women with endometrial cancer and found that factors like body weight and diabetes increase the risk for both younger and older women.
  • Educating women about these risk factors could help reduce the number of cases, as many endometrial cancer cases in both age groups are linked to these factors.
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  • - The study investigates how genetic variants affect the relationship between heavy alcohol consumption and the risk of pancreatic cancer, utilizing data from a sizable European ancestry population.
  • - Researchers identified a new relevant genomic region (10p11.22) linked to pancreatic cancer risk and a specific SNP (rs7898449) that suggests this association is influenced by heavy alcohol consumption.
  • - The findings highlight the potential role of the neuropilin 1 gene in pancreatic cancer development, offering new insights into cancer risk factors, especially among heavy drinkers.
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Background: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for endometrial cancer. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of endometrial cancer remains unclear.

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Background: A high body mass index (BMI, kg/m) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.

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