Ventilatory compensation for inspiratory resistive loads during anaesthesia with halothane or isoflurane.

We have analysed the ventilatory response to sustained inspiratory resistive loads in 14 patients, while awake and during halothane (n = 7) or isoflurane (n = 7) anaesthesia. Patients breathed halothane or isoflurane in oxygen at 1.2 minimum alveolar concentration (MAC).

Effects of halothane and isoflurane on ventilation and occlusion pressure.

Background: Isoflurane has been said to be more ventilatory depressant than halothane. However, data for comparing the respiratory effects of halothane and isoflurane in humans are insufficient at this time. The aim of this study was to extend our understanding of the nature of the central, as opposed to peripheral, ventilatory effect of halothane and isoflurane by comparing them at two concentrations.

A simple method for determining the rate of gastrointestinal transit in the rat.

A method is presented for the determination of gastric emptying and transit after a meal in the rat. It involves the administration of radioactive inulin, an undigestible, non-absorbable sugar.

The DDT method: an alternative to the use of radiolabelled microspheres for the determination of regional blood flows in the rat.

Intravenous administration of the 14C-radiolabelled insecticide DDT--1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane--can be used for the estimation of regional blood flows in small rodents. A mathematical model is presented which enables the conversion of relative into absolute blood flows.

The role of insulin in the intestinal absorption of glucose in the rat.

1. Acute pre-treatment with either mannoheptulose or streptozotocin--both compounds acting as powerful suppressors of insulin secretion--caused a significant decrease on the in vivo rate of intestinal glucose absorption following an intragastric [U-14C]glucose administration. 2.