Publications by authors named "A Zedet"

Arginase, a difficult-to-target metalloenzyme, is implicated in a wide range of diseases, including cancer, infectious, and cardiovascular diseases. Despite the medical need, existing inhibitors have limited structural diversity, consisting predominantly of amino acids and their derivatives. The search for innovative arginase inhibitors has now extended to screening approaches.

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The methanolic extract of the leaves of Beille showed arginase inhibitory activity (40% at 100 µg/mL) and was then fractionated to obtain nine polyphenolic compounds. Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in the literature, as gallic acid (), 3,4-dihydroxybenzoic acid (), chlorogenic acid, (), corilagin (), cynaroside (), cosmosiin (), hyperoside () isoquercitrin ( and guajaverin (). These compounds have been evaluated as arginase inhibitors.

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Arginase, which converts arginine into ornithine and urea, is a promising therapeutic target. Arginase is involved in cardiovascular diseases, parasitic infections and through a critical role in immunity, in some cancers. There is a need to develop effective arginase inhibitors and therefore efforts to identify and optimize new inhibitors are increasing.

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Essential oils (EOs) or their components are widely used by inhalation or nebulization to fight mild respiratory bacterial infections. However, their interaction with antibiotics is poorly known. In this study we evaluated the effects of citral, the main component of lemongrass oil, on susceptibility of to antibiotics.

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Polyphenolic enriched extracts from two species of , and , possess mammalian arginase inhibitory capacities, with the percentage inhibition ranging from 80% to 95% at 100 µg/mL and 40% to 64% at 10 µg/mL. Phytochemical investigation of these species led to the isolation and identification of two new natural stilbene oligomers named thunbergin A-B (-), together with three other stilbenes, -resveratrol (), -scirpusin A (), -cyperusphenol A (), and two flavonoids, aureusidin () and luteolin (), which were isolated for the first time from and . Structures were established on the basis of the spectroscopic data from MS and NMR experiments.

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