Publications by authors named "A Zavrelova"
Background: Febrile neutropenia (FN) is a common complication of stem cell transplantation.
Aim: To evaluate the frequency of sepsis in patients with FN colonized with resistant Gram-negative bacteria (extended-spectrum β-lactamase (ESBL)-positive, multidrug-resistant (MDR) Pseudomonas aeruginosa) and the choice of primary antibiotic in colonized patients.
Methods: This retrospective study analysed data from patients undergoing haematopoietic stem cell transplantation from January 2018 to September 2022.
Article Synopsis
- The removal of the mRNA 5' cap is key for gene expression regulation and leads to transcript degradation in eukaryotes.
- Unlike other eukaryotes, Kinetoplastida, such as T. brucei, use the ALPH1 enzyme for decapping instead of the typical Dcp2 enzyme, and ALPH1 forms complexes with several unique Kinetoplastida proteins.
- The structure and localization of ALPH1, particularly its C- and N-terminal regions, are crucial for its interaction with other proteins and RNA granules, indicating distinct regulatory mechanisms compared to other organisms.
Background: sepsis in immunocompromised patients is a serious complication of cancer treatment, especially in the case of an Extensively Drug Resistant (XDR) pathogen. The aim of the study is to evaluate the efficacy of high-dose ceftazidime in the treatment of XDR infection and to compare it with the conventionally treated cohort in hemato-oncological patients.
Methods: We identified 27 patients with XDR infection during the 2008-2018 period, 16 patients served as a conventionally treated cohort with an antipseudomonal beta-lactam antibiotic in standard dose (cohort A), and 11 patients were treated with high-dose ceftazidime (cohort B).
Aim: The objective of this study was to evaluate off-label high-dose ceftazidime population pharmacokinetics in cancer patients with suspected or proven extensively drug-resistant (XDR) Pseudomonas aeruginosa infections and then to compare the achievement of the pharmacokinetic/pharmacodynamic (PK/PD) target after standard and off-label high-dose regimens using population model-based simulations. A further aim was to clinically observe the occurrence of adverse effects during the off-label high-dose ceftazidime treatment.
Methods: In patients treated with off-label high-dose ceftazidime (3 g every 6 h), blood samples were collected and ceftazidime serum levels measured using LC-MS/MS.
Mycobacterioses are less frequently occurring but serious diseases. In recent years, at a global level, the incidence of mycobacterioses induced by the rapidly growing species (), which is considered to be the most resistant to antibiotics and most difficult to treat, has been on the rise. Correct identification to the level of the subspecies (, , and ) and determination of its sensitivity to macrolides, which are the basis of combination therapy, are of principal importance for the management of the disease.
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